Associated Papers
Burden of Mendelian disorders in a large Middle Eastern biobank.
Aamer W et al.
Genome Medicine, 2024
The CB1 receptor interacts with cereblon and drives cereblon deficiency-associated memory shortfalls.
Costas-Insua C et al.
Embo Molecular Medicine, 2024
Large-conductance calcium-activated potassium channel haploinsufficiency leads to sensory deficits in the visual system: a case report.
Perche O et al.
Journal of Medical Case Reports, 2022
Novel Molecular Mechanism of Lenalidomide in Myeloid Malignancies Independent of Deletion of Chromosome 5q.
Park I et al.
Cancers, 2021
Cereblon-mediated degradation of the amyloid precursor protein via the ubiquitin-proteasome pathway.
Kurihara T et al.
Biochemical and Biophysical Research Communications, 2020
Cereblon attenuates DNA damage-induced apoptosis by regulating the transcription-independent function of p53.
Zhou L et al.
Cell Death & Disease, 2019
Cereblon Maintains Synaptic and Cognitive Function by Regulating BK Channel.
Choi TY et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2018
Rescue of Learning and Memory Deficits in the Human Nonsyndromic Intellectual Disability Cereblon Knock-Out Mouse Model by Targeting the AMP-Activated Protein Kinase-mTORC1 Translational Pathway.
Bavley CC et al.
The Journal of Neuroscience : the Official Journal of the Society for Neuroscience, 2018
CRL4 antagonizes SCFFbxo7-mediated turnover of cereblon and BK channel to regulate learning and memory.
Song T et al.
Plos Genetics, 2018
A Comprehensive Atlas of E3 Ubiquitin Ligase Mutations in Neurological Disorders.
George AJ et al.
Frontiers in Genetics, 2018
A missense mutation in the CRBN gene that segregates with intellectual disability and self-mutilating behaviour in a consanguineous Saudi family.
Sheereen A et al.
Journal of Medical Genetics, 2017
Genetic upregulation of BK channel activity normalizes multiple synaptic and circuit defects in a mouse model of fragile X syndrome.
Deng PY et al.
The Journal of Physiology, 2016
Cereblon is recruited to aggresome and shows cytoprotective effect against ubiquitin-proteasome system dysfunction.
Sawamura N et al.
Biochemical and Biophysical Research Communications, 2015
Structural dynamics of the cereblon ligand binding domain.
Hartmann MD et al.
Plos One, 2015
Functional effects of a pathogenic mutation in Cereblon (CRBN) on the regulation of protein synthesis via the AMPK-mTOR cascade.
Lee KM et al.
The Journal of Biological Chemistry, 2014
Absence of mutations in cereblon (CRBN) and DNA damage-binding protein 1 (DDB1) genes and significance for IMiD therapy.
Thakurta A et al.
Leukemia, 2014
Genetics of recessive cognitive disorders.
Musante L et al.
Trends in Genetics : Tig, 2014
A mental retardation-linked nonsense mutation in cereblon is rescued by proteasome inhibition.
Xu G et al.
The Journal of Biological Chemistry, 2013
Pure partial monosomy 3p (3p25.3 → pter): prenatal diagnosis and array comparative genomic hybridization characterization.
Chen CP et al.
Taiwanese Journal of Obstetrics & Gynecology, 2012
Behavioral characterization of cereblon forebrain-specific conditional null mice: a model for human non-syndromic intellectual disability.
Rajadhyaksha AM et al.
Behavioural Brain Research, 2012
What is the functional role of the thalidomide binding protein cereblon?
Chang XB et al.
International Journal of Biochemistry and Molecular Biology, 2011
Identification of a primary target of thalidomide teratogenicity.
Ito T et al.
Science (new York, N.y.), 2010
Temporal and spatial mouse brain expression of cereblon, an ionic channel regulator involved in human intelligence.
Higgins JJ et al.
Journal of Neurogenetics, 2010
Cereblon is expressed in the retina and binds to voltage-gated chloride channels.
Hohberger B et al.
Febs Letters, 2009
Dysregulation of large-conductance Ca2+-activated K+ channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation.
Higgins JJ et al.
Neurogenetics, 2008
Genetics of autosomal recessive non-syndromic mental retardation: recent advances.
Basel-Vanagaite L
Clinical Genetics, 2007
A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation.
Higgins JJ et al.
Neurology, 2004