Associated Papers
A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation.
Langousis G et al.
Nature Communications, 2025
Continuous evolution of compact protein degradation tags regulated by selective molecular glues.
Mercer JAM et al.
Science (new York, N.y.), 2024
Cereblon neo-substrate binding mimics the recognition of the cyclic imide degron.
Heim C et al.
Biochemical and Biophysical Research Communications, 2023
IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling.
Dunbar K et al.
Life Science Alliance, 2021
Thalidomide Inhibits Human iPSC Mesendoderm Differentiation by Modulating CRBN-dependent Degradation of SALL4.
Belair DG et al.
Scientific Reports, 2020
Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome.
Donovan KA et al.
Elife, 2018
Ligand-mediated protein degradation reveals functional conservation among sequence variants of the CUL4-type E3 ligase substrate receptor cereblon.
Akuffo AA et al.
The Journal of Biological Chemistry, 2018
A novel cereblon modulator recruits GSPT1 to the CRL4(CRBN) ubiquitin ligase.
Matyskiela ME et al.
Nature, 2016
Structural basis of lenalidomide-induced CK1α degradation by the CRL4(CRBN) ubiquitin ligase.
Petzold G et al.
Nature, 2016
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