Varaico: Literature-Extracted Genetic Variants

Gene:CRBN
Variant:p.E377K
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CRBN

NM_016302.4:p.E377K

Associated Papers

A degron-mimicking molecular glue drives CRBN homo-dimerization and degradation.

Langousis G et al.

Nature Communications, 2025

41258141 (PubMed )
Supplement: 41467_2025_65094_MOESM5_ESM.pdf

Functional E3 ligase hotspots and resistance mechanisms to small-molecule degraders.

Hanzl A et al.

Nature Chemical Biology, 2023

The genetic heterogeneity and drug resistance mechanisms of relapsed refractory multiple myeloma.

Vo JN et al.

Nature Communications, 2022

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."