Varaico: Literature-Extracted Genetic Variants

Gene:CRBN
Variant:p.R283K
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CRBN

NM_016302.4:p.R283K

Associated Papers

Evaluating the impact of CRBN mutations on response to immunomodulatory drugs and novel cereblon E3 ligase modulators in myeloma.

Chrisochoidou Y et al.

Blood, 2025

Advances in the molecular characterization of multiple myeloma and mechanism of therapeutic resistance.

Mejia Saldarriaga M et al.

Frontiers in Oncology, 2022

Clinical Implementation of Integrated Genomic Profiling in Patients with Advanced Cancers.

Borad MJ et al.

Scientific Reports, 2016

Absence of mutations in cereblon (CRBN) and DNA damage-binding protein 1 (DDB1) genes and significance for IMiD therapy.

Thakurta A et al.

Leukemia, 2014

Extramedullary myeloma whole genome sequencing reveals novel mutations in Cereblon, proteasome subunit G2 and the glucocorticoid receptor in multi drug resistant disease.

Egan JB et al.

British Journal of Haematology, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."