Varaico: Literature-Extracted Genetic Variants

Gene:CREBRF
Variant:p.R457Q
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CREBRF

NM_153607.3:p.R457Q

Associated Papers

Interplay between obesity-associated insulin resistance and immune system through the lens of evolutionary medicine.

Moazzam-Jazi M et al.

Molecular Metabolism, 2026

Polygenic and single-locus selection on BMI during Polynesian expansion.

Miwa H et al.

Journal of Human Genetics, 2025

Gut microbial composition and diversity varies by CREBRF genotype among Samoan infants.

Oyama S et al.

Physiological Genomics, 2025

The impact of CREBRF rs373863828 Pacific-variant on infant body composition.

Amitrano F et al.

Scientific Reports, 2024

Associations between fasting glucose rate-of-change and the missense variant, rs373863828, in an adult Samoan cohort.

Rivara AC et al.

Plos One, 2024

Tree-based QTL mapping with expected local genetic relatedness matrices.

Link V et al.

American Journal of Human Genetics, 2023

Genetics of metabolic traits in Greenlanders.

Thuesen ACB et al.

Danish Medical Journal, 2023

The protective effect of rs373863828 on type 2 diabetes does not operate through a body composition pathway in adult Samoans.

Hawley NL et al.

Obesity (silver Spring, Md.), 2022

Generation of a genetically modified pig model with CREBRFR457Q variant.

Li Y et al.

Faseb Journal : Official Publication of the Federation of American Societies for Experimental Biology, 2022

The minor allele of the CREBRF rs373863828 p.R457Q coding variant is associated with reduced levels of myostatin in males: Implications for body composition.

Lee K et al.

Molecular Metabolism, 2022

Limited Metabolic Effect of the CREBRFR457Q Obesity Variant in Mice.

Metcalfe LK et al.

Cells, 2022

The CREBRF diabetes-protective rs373863828-A allele is associated with enhanced early insulin release in men of Māori and Pacific ancestry.

Burden HJ et al.

Diabetologia, 2021

Mid-pass whole genome sequencing enables biomedical genetic studies of diverse populations.

Emde AK et al.

Bmc Genomics, 2021

A missense variant in CREBRF, rs373863828, is associated with fat-free mass, not fat mass in Samoan infants.

Arslanian KJ et al.

International Journal of Obesity (2005), 2021

A murine model of the human CREBRFR457Q obesity-risk variant does not influence energy or glucose homeostasis in response to nutritional stress.

Kanshana JS et al.

Plos One, 2021

A missense variant in CREBRF is associated with taller stature in Samoans.

Carlson JC et al.

American Journal of Human Biology : the Official Journal of the Human Biology Council, 2020

The Pacific-specific CREBRF rs373863828 allele protects against gestational diabetes mellitus in Māori and Pacific women with obesity.

Krishnan M et al.

Diabetologia, 2020

Exploring the Paradoxical Relationship of a Creb 3 Regulatory Factor Missense Variant With Body Mass Index and Diabetes Among Samoans: Protocol for the Soifua Manuia (Good Health) Observational Cohort Study.

Hawley NL et al.

Jmir Research Protocols, 2020

The Māori and Pacific specific CREBRF variant and adult height.

Metcalfe LK et al.

International Journal of Obesity (2005), 2020

Crebl2 regulates cell metabolism in muscle and liver cells.

Tiebe M et al.

Scientific Reports, 2019

Association of CREBRF variants with obesity and diabetes in Pacific Islanders from Guam and Saipan.

Hanson RL et al.

Diabetologia, 2019

The Genetic Basis of Metabolic Disease.

Barroso I et al.

Cell, 2019

The Role of Mammalian Creb3-Like Transcription Factors in Response to Nutrients.

Khan HA et al.

Frontiers in Genetics, 2019

Genetics of metabolic traits in Greenlanders: lessons from an isolated population.

Andersen MK et al.

Journal of Internal Medicine, 2018

Re: "Widespread prevalence of a CREBRF variant among Māori and Pacific children is associated with weight and height in early childhood".

Major TJ et al.

International Journal of Obesity (2005), 2018

Genomic insights into the causes of type 2 diabetes.

Langenberg C et al.

Lancet (london, England), 2018

Association study of CREBRF missense variant (rs373863828:G > A; p.Arg457Gln) with levels of serum lipid profile in the Pacific populations.

Ohashi J et al.

Annals of Human Biology, 2018

Widespread prevalence of a CREBRF variant amongst Māori and Pacific children is associated with weight and height in early childhood.

Berry SD et al.

International Journal of Obesity (2005), 2018

Single-Step qPCR and dPCR Detection of Diverse CRISPR-Cas9 Gene Editing Events In Vivo.

Falabella M et al.

G3 (bethesda, Md.), 2017

A missense variant, rs373863828-A (p.Arg457Gln), of CREBRF and body mass index in Oceanic populations.

Naka I et al.

Journal of Human Genetics, 2017

Obesity: BMI-increasing variant identified in Samoans.

Holmes D

Nature Reviews. Endocrinology, 2016

A thrifty variant in CREBRF strongly influences body mass index in Samoans.

Minster RL et al.

Nature Genetics, 2016

CREBRF variant increases obesity risk and protects against diabetes in Samoans.

Loos RJ

Nature Genetics, 2016

Genomic landscape of the Greater Middle East.

Özçelik T et al.

Nature Genetics, 2016

The missense variant, rs373863828, in CREBRF plays a role in longitudinal changes in body mass index in Samoans.

Fu H et al.

Obesity Research & Clinical Practice, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."