Varaico: Literature-Extracted Genetic Variants

Gene:CRLF2
Variant:p.F232C
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CRLF2

NM_022148.4:p.F232C

Associated Papers

Application of Targeted RNA-Sequencing in High-Risk B-Cell Acute Lymphoblastic Leukemia (B-ALL): Identifying Fusions, IKZF1 Deletions, and CRLF2 Expression in an Indian Cohort.

Gupta SK et al.

International Journal of Laboratory Hematology, 2026

Leveraging genomic diagnostics for prognostics and therapeutics in pediatric acute leukemia.

Newman H et al.

Hemasphere, 2025

41306327 (PubMed )
Supplement: HEM3-9-e70269-s013.xlsx › Supplemental_Table_5_-_SSVs

Enhancer RNAs contribute to genome reprogramming driven by a GATA3 noncoding variant in leukaemia.

da Conceição Barbosa T et al.

Scientific Reports, 2025

Genomic and Clinicopathological Characterization of CRLF2-Rearranged Mixed Phenotype Acute Leukemia.

Han L et al.

Pediatric Blood & Cancer, 2025

Diagnostic genomic analysis is prognostic in AYA patients with ALL treated on an MRD-stratified pediatric protocol.

Yeung DT et al.

Blood Neoplasia, 2025

Preferential Genetic Pathways Lead to Relapses in Adult B-Cell Acute Lymphoblastic Leukemia.

Navas-Acosta J et al.

Cancers, 2024

39766099 (PubMed )
Supplement: cancers-16-04200-s001.zip › Supplementary_tables_Cancers2024.xlsx › Table_S4

The application of targeted RNA sequencing for the analysis of fusion genes, gene mutations, IKZF1 intragenic deletion, and CRLF2 overexpression in acute lymphoblastic leukemia.

Zhang Z et al.

International Journal of Laboratory Hematology, 2024

RNA-seq-based miRNA signature as an independent predictor of relapse in pediatric B-cell acute lymphoblastic leukemia.

Kubota H et al.

Blood Advances, 2024

38127276 (PubMed )
Supplement: BLOODA_ADV-2023-011583-mmc1.xlsx › Sup.9

Predictive and prognostic molecular biomarkers in lymphomas.

Iorgulescu JB et al.

Pathology, 2024

Detection of Hybrid Fusion Transcripts, Aberrant Transcript Expression, and Specific Single Nucleotide Variants in Acute Leukemia and Myeloid Disorders with Recurrent Gene Rearrangements.

Li Y et al.

Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology, 2024

Comprehensive detection of CRLF2 alterations in acute lymphoblastic leukemia: a rapid and accurate novel approach.

Gil JV et al.

Frontiers in Molecular Biosciences, 2024

Prognostic Impact of Copy Number Alterations' Profile and AID/RAG Signatures in Acute Lymphoblastic Leukemia (ALL) with BCR::ABL and without Recurrent Genetic Aberrations (NEG ALL) Treated with Intensive Chemotherapy.

Libura M et al.

Cancers, 2023

38001691 (PubMed )
Supplement: cancers-15-05431-s001.zip › cancers-2681173-supplementary.pdf

Mining cancer genomes for change-of-metabolic-function mutations.

Tu KJ et al.

Communications Biology, 2023

37950065 (PubMed )
Supplement: 42003_2023_5475_MOESM2_ESM.pdf

Classification and genetics of pediatric B-other acute lymphoblastic leukemia by targeted RNA sequencing.

Migita NA et al.

Blood Advances, 2023

New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation.

Arwood ML et al.

Cell Chemical Biology, 2023

Integrative genomic analysis of childhood acute lymphoblastic leukaemia lacking a genetic biomarker in the UKALL2003 clinical trial.

Schwab C et al.

Leukemia, 2023

36550215 (PubMed )
Supplement: 41375_2022_1799_MOESM1_ESM.pdf

RaScALL: Rapid (Ra) screening (Sc) of RNA-seq data for prognostically significant genomic alterations in acute lymphoblastic leukaemia (ALL).

Rehn J et al.

Plos Genetics, 2022

Characterization of Philadelphia-like Pre-B Acute Lymphoblastic Leukemia: Experiences in Mexican Pediatric Patients.

Martínez-Anaya D et al.

International Journal of Molecular Sciences, 2022

Whole-transcriptome analysis in acute lymphoblastic leukemia: a report from the DFCI ALL Consortium Protocol 16-001.

Tran TH et al.

Blood Advances, 2022

34933343 (PubMed )
Supplement: advancesADV2021005634-suppl1.xlsx › S3_Mutation_details

IKZF1 deletions associate with CRLF2 overexpression leading to a poor prognosis in B-cell precursor acute lymphoblastic leukaemia.

Maciel ALT et al.

Translational Oncology, 2022

BCR/ABL1-Like Acute Lymphoblastic Leukemia: From Diagnostic Approaches to Molecularly Targeted Therapy.

Płotka A et al.

Acta Haematologica, 2022

Genomes for Kids: The Scope of Pathogenic Mutations in Pediatric Cancer Revealed by Comprehensive DNA and RNA Sequencing.

Newman S et al.

Cancer Discovery, 2021

34301788 (PubMed )
Supplement: cd-20-1631_supplementary_tables_suppst1.xlsx › S2.Somatic_Findings_Summary

Transcriptional and Mutational Profiling of B-Other Acute Lymphoblastic Leukemia for Improved Diagnostics.

Chouvarine P et al.

Cancers, 2021

Biologic and Therapeutic Implications of Genomic Alterations in Acute Lymphoblastic Leukemia.

Iacobucci I et al.

Journal of Clinical Medicine, 2021

Deregulation of the Interleukin-7 Signaling Pathway in Lymphoid Malignancies.

Lodewijckx I et al.

Pharmaceuticals (basel, Switzerland), 2021

Genetic Alterations and Therapeutic Targeting of Philadelphia-Like Acute Lymphoblastic Leukemia.

Iacobucci I et al.

Genes, 2021

Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.

Hescheler DA et al.

Frontiers in Endocrinology, 2021

34630336 (PubMed )
Supplement: Table_1.xlsx › Tab2

Comprehensive Custom NGS Panel Validation for the Improvement of the Stratification of B-Acute Lymphoblastic Leukemia Patients.

Montaño A et al.

Journal of Personalized Medicine, 2020

A novel targeted RNA-Seq panel identifies a subset of adult patients with acute lymphoblastic leukemia with BCR-ABL1-like characteristics.

Sánchez R et al.

Blood Cancer Journal, 2020

32332702 (PubMed )
Supplement: 41408_2020_308_MOESM2_ESM.xlsx › Hoja1

BCR-ABL1-like B-Acute Lymphoblastic Leukemia/Lymphoma: A Comprehensive Review.

Jain S et al.

Archives of Pathology & Laboratory Medicine, 2020

Genomic landscape of pediatric B-other acute lymphoblastic leukemia in a consecutive European cohort.

Zaliova M et al.

Haematologica, 2019

BCR/ABL1-like acute lymphoblastic leukemia: How to diagnose and treat?

Chiaretti S et al.

Cancer, 2019

Precision medicine approaches may be the future for CRLF2 rearranged Down Syndrome Acute Lymphoblastic Leukaemia patients.

Page EC et al.

Cancer Letters, 2018

Advances in B-cell Precursor Acute Lymphoblastic Leukemia Genomics.

Schwab C et al.

Hemasphere, 2018

Differential expression of MUC4, GPR110 and IL2RA defines two groups of CRLF2-rearranged acute lymphoblastic leukemia patients with distinct secondary lesions.

Sadras T et al.

Cancer Letters, 2017

Philadelphia Chromosome-like Acute Lymphoblastic Leukemia.

Pui CH et al.

Clinical Lymphoma, Myeloma & Leukemia, 2017

Mutations in TP53 and JAK2 are independent prognostic biomarkers in B-cell precursor acute lymphoblastic leukaemia.

Forero-Castro M et al.

British Journal of Cancer, 2017

Genomic and transcriptional landscape of P2RY8-CRLF2-positive childhood acute lymphoblastic leukemia.

Vesely C et al.

Leukemia, 2017

Characterisation of the genomic landscape of CRLF2-rearranged acute lymphoblastic leukemia.

Russell LJ et al.

Genes, Chromosomes & Cancer, 2017

28033648 (PubMed )
Supplement: GCC-56-363-s002.xlsx › Supplementary_Table_9
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."