Varaico: Literature-Extracted Genetic Variants

Gene:CRTC2
Variant:p.S171A
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CRTC2

NM_181715.3:p.S171A

Associated Papers

The CREB coactivator CRTC2 promotes oncogenesis in LKB1-mutant non-small cell lung cancer.

Rodón L et al.

Science Advances, 2019

Analysis of a cAMP regulated coactivator family reveals an alternative phosphorylation motif for AMPK family members.

Sonntag T et al.

Plos One, 2017

The CREB coactivator CRTC2 controls hepatic lipid metabolism by regulating SREBP1.

Han J et al.

Nature, 2015

The CREB Coactivator CRTC2 Is a Lymphoma Tumor Suppressor that Preserves Genome Integrity through Transcription of DNA Mismatch Repair Genes.

Fang M et al.

Cell Reports, 2015

CRTC2 is required for β-cell function and proliferation.

Eberhard CE et al.

Endocrinology, 2013

Orphan nuclear receptor estrogen-related receptor γ (ERRγ) is key regulator of hepatic gluconeogenesis.

Kim DK et al.

The Journal of Biological Chemistry, 2012

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin.

Shaw RJ et al.

Science (new York, N.y.), 2005

16308421 (PubMed )
Supplement: shaw.som.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."