Associated Papers
Decoding the mechanisms of cooperative DNA binding by the Paired-like homeodomain family.
Cain B et al.
Biorxiv : the Preprint Server for Biology, 2025
The ALX4 dimer structure provides insight into how disease alleles impact function.
Cain B et al.
Nature Communications, 2025
Systematic review of genotype-phenotype associations in CRX-associated retinal dystrophies.
Banjak M et al.
Bmj Open Ophthalmology, 2025
Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models.
Zheng Y et al.
Genome Research, 2025
Dual inheritance patterns: A spectrum of non-syndromic inherited retinal disease phenotypes with varying molecular mechanisms.
Holtes LK et al.
Progress in Retinal and Eye Research, 2025
Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain.
Shepherdson JL et al.
Genome Research, 2024
Molecular basis of CRX/DNA recognition and stoichiometry at the Ret4 response element.
Srivastava D et al.
Structure (london, England : 1993), 2024
Mutational scanning of CRX classifies clinical variants and reveals biochemical properties of the transcriptional effector domain.
Shepherdson JL et al.
Biorxiv : the Preprint Server for Biology, 2024
Aberrant homeodomain-DNA cooperative dimerization underlies distinct developmental defects in two dominant CRX retinopathy models.
Zheng Y et al.
Biorxiv : the Preprint Server for Biology, 2024
Transcriptional precision in photoreceptor development and diseases - Lessons from 25 years of CRX research.
Zheng Y et al.
Frontiers in Cellular Neuroscience, 2024
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms.
Zheng Y et al.
Elife, 2023
Missense mutations in CRX homeodomain cause dominant retinopathies through two distinct mechanisms.
Zheng Y et al.
Biorxiv : the Preprint Server for Biology, 2023
Disease-causing mutations in genes encoding transcription factors critical for photoreceptor development.
Sun C et al.
Frontiers in Molecular Neuroscience, 2023
Gene Augmentation for Autosomal Dominant CRX-Associated Retinopathies.
Sun C et al.
Advances in Experimental Medicine and Biology, 2023
Pathogenicity discrimination and genetic test reference for CRX variants based on genotype-phenotype analysis.
Yi Z et al.
Experimental Eye Research, 2019
Mechanisms of blindness: animal models provide insight into distinct CRX-associated retinopathies.
Tran NM et al.
Developmental Dynamics : an Official Publication of the American Association of Anatomists, 2014
The phenotypic variability of retinal dystrophies associated with mutations in CRX, with report of a novel macular dystrophy phenotype.
Hull S et al.
Investigative Ophthalmology & Visual Science, 2014
Mechanistically distinct mouse models for CRX-associated retinopathy.
Tran NM et al.
Plos Genetics, 2014
CRX variants in cone-rod dystrophy and mutation overview.
Huang L et al.
Biochemical and Biophysical Research Communications, 2012
Next-generation genetic testing for retinitis pigmentosa.
Neveling K et al.
Human Mutation, 2012
Two novel CRX mutant proteins causing autosomal dominant Leber congenital amaurosis interact differently with NRL.
Nichols LL et al.
Human Mutation, 2010
Genotype-phenotype correlation in a German family with a novel complex CRX mutation extending the open reading frame.
Paunescu K et al.
Ophthalmology, 2007
Molecular analysis of a human PAX6 homeobox mutant.
D'Elia AV et al.
European Journal of Human Genetics : Ejhg, 2006
Homeodomain revisited: a lesson from disease-causing mutations.
Chi YI
Human Genetics, 2005
The photoreceptor-specific nuclear receptor Nr2e3 interacts with Crx and exerts opposing effects on the transcription of rod versus cone genes.
Peng GH et al.
Human Molecular Genetics, 2005
Interference of Crx-dependent transcription by ataxin-7 involves interaction between the glutamine regions and requires the ataxin-7 carboxy-terminal region for nuclear localization.
Chen S et al.
Human Molecular Genetics, 2004
Barrier to autointegration factor interacts with the cone-rod homeobox and represses its transactivation function.
Wang X et al.
The Journal of Biological Chemistry, 2002
Dominant Leber congenital amaurosis, cone-rod degeneration, and retinitis pigmentosa caused by mutant versions of the transcription factor CRX.
Rivolta C et al.
Human Mutation, 2001
Prevalence of mutations causing retinitis pigmentosa and other inherited retinopathies.
Sohocki MM et al.
Human Mutation, 2001
Functional domains of the cone-rod homeobox (CRX) transcription factor.
Chau KY et al.
The Journal of Biological Chemistry, 2000
Nuclear trafficking of photoreceptor protein crx: the targeting sequence and pathologic implications.
Fei Y et al.
Investigative Ophthalmology & Visual Science, 2000
A retGC-1 mutation in autosomal dominant cone-rod dystrophy.
Perrault I et al.
American Journal of Human Genetics, 1998
Partial V(D)J recombination activity leads to Omenn syndrome.
Villa A et al.
Cell, 1998
De novo mutations in the CRX homeobox gene associated with Leber congenital amaurosis.
Freund CL et al.
Nature Genetics, 1998
Cone-rod dystrophy due to mutations in a novel photoreceptor-specific homeobox gene (CRX) essential for maintenance of the photoreceptor.
Freund CL et al.
Cell, 1997