Varaico: Literature-Extracted Genetic Variants

Gene:CTLA4
Variant:p.T17A
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CTLA4

NM_005214.5:p.T17A

Associated Papers

Association of CTLA-4 exon 1(+49 A/G) polymorphism and susceptibility to SLE in Egyptian children and adolescents.

Arab F et al.

Lupus, 2026

CTLA4, PTNP22, and FOXO3A gene variants as genetic biomarkers for co-occurrence of type 1 diabetes and autoimmune thyroid diseases in the Polish population.

Cichocka E et al.

Polish Archives of Internal Medicine, 2026

Non-HLA risk variants in a type 1 diabetes pediatric population: Clinical and autoimmune profiles.

Díez Blanco M et al.

Anales De Pediatria, 2026

Association of immune relevant single nucleotide polymorphisms with ALK-positive anaplastic large cell lymphoma presentation and outcome: results of the immuno ALCL study.

Adriana P et al.

Journal of Translational Medicine, 2025

Functional genetic variants in immune-checkpoint molecules and susceptibility to Nasopharyngeal carcinoma in a Tunisian case-control study.

Gharbi W et al.

Molecular Biology Reports, 2025

CTLA4 genetic variants influence immune regulation and susceptibility of HPV associated cervical cancer.

de Oliveira MC et al.

Discover Oncology, 2025

Allele frequency of CTLA-4 rs231775 (+49 A>G) gene polymorphism and its association with cancer susceptibility in the Saudi Arabian population and other ethnic groups.

Akhtar MS et al.

Cellular and Molecular Biology (noisy-le-grand, France), 2025

Germline Variants in the Immune Response-Related Genes: Possible Modifying Effect on Age-Dependent BRCA1 Penetrance in Breast Cancer Patient.

Kuligina ES et al.

Cancers, 2025

41374957 (PubMed )
Supplement: cancers-17-03756-s001.zip › Table_S4a.xlsx › Table_S4a

Exploratory Study on Genetic Variants Related to Hydatidosis Susceptibility and Albendazole Pharmacogenetics in the Cusco Region in Peru.

Jaramillo-Valverde L et al.

Frontiers in Bioscience (scholar Edition), 2025

Cytotoxic T-Lymphocyte Antigen-4 (CTLA-4) gene polymorphism is associated with pulmonary tuberculosis susceptibility in a Thai population.

Tiwongsa P et al.

Tropical Biomedicine, 2025

Clinical Impact of CTLA-4 Single-Nucleotide Polymorphism in DLBCL Patients Treated with CAR-T Cell Therapy.

Seipel K et al.

Current Oncology (toronto, Ont.), 2025

Human iPSC-based breast cancer model identifies S100P-dependent cancer stemness induced by BRCA1 mutation.

Liu J et al.

Science Advances, 2025

40712032 (PubMed )
Supplement: sciadv.adi2370_tables_s8_and_s9.zip › adi2370_table_s9.xlsx › BRCA1-mutant_corrected_iPSC

Assessment of the potential impact of polymorphisms in the Foxp3 and CTLA-4 genes in immune balance and disease susceptibility of primary Sjögren's syndrome.

Feng M et al.

Pharmacogenetics and Genomics, 2025

Is there a role of genetics in acute and chronic urticaria-A systematic review and meta-analysis.

Konstantinou GN et al.

Clinical and Translational Allergy, 2025

The Genetic Background of Ankylosing Spondylitis Reveals a Distinct Overlap with Autoimmune Diseases: A Systematic Review.

Zormpa T et al.

Journal of Clinical Medicine, 2025

40507438 (PubMed )
Supplement: jcm-14-03677-s001.zip › Supplementary_Table_S1.xlsx › Sheet1

CD274 (PD-L1) Polymorphisms as Predictors of Efficacy in First-Line Platinum-Based Chemotherapy for Extensive-Stage Small Cell Lung Cancer.

Barba A et al.

International Journal of Molecular Sciences, 2025

CTLA4 Haplotype Structures and -318 C>T (rs5742909) Genetic Variant Contribute to the Susceptibility of HPV Infection and Cervical Cancer.

de Oliveira MC et al.

Viruses, 2025

Efficacy of CLT4A variants as immunoregulatory molecules among Vitiligo patients in Saudi Arabia.

Alshammary AF et al.

Scientific Reports, 2025

Translational and clinical comparison of whole genome and transcriptome to panel sequencing in precision oncology.

Kerle IA et al.

Npj Precision Oncology, 2025

39794422 (PubMed )
Supplement: 41698_2024_788_MOESM7_ESM.xlsx › patient_10_panel_small_variants

Epidermal second-hit mutation in MVK gene associated with linear porokeratosis.

Zhao A et al.

Genes & Diseases, 2025

39386107 (PubMed )
Supplement: mmc2.xlsx › standard

The Polygenic Nature of Multiple Sclerosis: Genetic Variants, Immunological Modulation, and Environmental Connections.

Khan Z et al.

Endocrine, Metabolic & Immune Disorders Drug Targets, 2025

The Association between PTPN22 SNPs and susceptibility to type 1 diabetes: An updated meta-analysis.

Su Y et al.

Plos One, 2025

40238817 (PubMed )
Supplement: pone.0321624.s008.pdf

Association between CTLA4 polymorphisms and susceptibility to granulomatosis with polyangiitis.

Mohamadi A et al.

International Reviews of Immunology, 2025

Genetic architecture of primary biliary cholangitis: strong evidence for HLA and non-HLA risk loci.

Zhang M et al.

Frontiers in Immunology, 2025

STAT4 (rs7574865) Polymorphism and Serum STAT4 Levels in Rheumatoid Arthritis Susceptibility, Severity, and Treatment Response: A Case-Control Study in Iraqi Patients.

Abdalhussein AR et al.

Iranian Journal of Pathology, 2025

Circulating Cytotoxic T lymphocytes associated antigen-4 (CTLA-4) levels and CTLA-4 gene polymorphism role in head and neck squamous cell carcinoma.

Rashid HH et al.

Wiadomosci Lekarskie (warsaw, Poland : 1960), 2025

TIM3 and CTLA4 immune checkpoint polymorphisms are associated with acute myeloid leukemia in Saudi Arabia.

Alqahtani M et al.

Hematology (amsterdam, Netherlands), 2024

CTLA4 genetic variants associated with urothelial bladder cancer susceptibility.

Koike A et al.

Urologic Oncology, 2024

Effect of DNA methylation at the CTLA4 gene on the clinical status of autoimmune thyroid diseases.

Ohtani H et al.

Clinical Immunology (orlando, Fla.), 2024

Association of four CTLA-4 gene polymorphisms with pemphigus risk: a systematic review, meta-analysis, and meta-regression.

Dhaouadi T et al.

The Journal of International Medical Research, 2024

Decoding the genetic influence of CT60 non-coding polymorphism in CTLA-4 gene and sCTLA-4 biomarker with rheumatoid arthritis in the Indian population.

Shamala V et al.

Molecular Biology Reports, 2024

The Role of Vitamin D Metabolism Genes and Their Genomic Background in Shaping Cyclosporine A Dosage Parameters after Kidney Transplantation.

Kotowska K et al.

Journal of Clinical Medicine, 2024

Relationship Between Cytotoxic T-Lymphocyte-associated Antigen-4: Programmed Death-1 Genes Polymorphisms and Susceptibility to Pediatric B-Cell Acute Lymphoblastic Leukemia.

Aref S et al.

Journal of Pediatric Hematology/oncology, 2024

Association of CTLA-4 (AT)n Variants in Basal Cell Carcinoma and Squamous Cell Carcinoma Patients from Western Mexico.

Rojas-Diaz JM et al.

Current Issues in Molecular Biology, 2024

Characteristics of Human Leukocyte Antigen Class II Genes in Japanese Patients with Type 1 Diabetes and Autoimmune Thyroid Disease.

Kajita R et al.

The Tohoku Journal of Experimental Medicine, 2024

Novel Genetic Variants Distinguishing Myelin Oligodendrocyte Glycoprotein-IgG-Positive From Myelin Oligodendrocyte Glycoprotein-IgG-Negative Pediatric Acute Disseminated Encephalomyelitis in Northern China.

Cui Y et al.

Pediatric Neurology, 2024

Efficacy of immunotherapy in ARID1A-mutant solid tumors: a single-center retrospective study.

Zhou H et al.

Discover Oncology, 2024

38847966 (PubMed )
Supplement: 12672_2024_1074_MOESM2_ESM.xlsx › Sheet1

Effects of CTLA-4 Single Nucleotide Polymorphisms on Toxicity of Ipilimumab-Containing Regimens in Patients With Advanced Stage Melanoma.

de Joode K et al.

Journal of Immunotherapy (hagerstown, Md. : 1997), 2024

Combining germline, tissue and liquid biopsy analysis by comprehensive genomic profiling to improve the yield of actionable variants in a real-world cancer cohort.

Vanni I et al.

Journal of Translational Medicine, 2024

38750555 (PubMed )
Supplement: 12967_2024_5227_MOESM14_ESM.xlsx › S14

Immunotherapy for colorectal cancer: insight from inherited genetics.

Tjader NP et al.

Trends in Cancer, 2024

CTLA-4 expression and polymorphisms in Schizophrenia; a systematic review of literature.

Fayedeh F et al.

Molecular Biology Reports, 2024

Cytotoxic T lymphocyte-associated antigen-4 (CTLA-4) gene polymorphisms in a cohort of Egyptian patients with immune thrombocytopenia (ITP).

El Demerdash DM et al.

Blood Research, 2024

Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) +49A>G (rs231775) gene polymorphism is not associated with COVID-19 severity and mortality in an Iranian population.

Mirsharif ES et al.

Heliyon, 2024

Review - The impact of pharmacogenetics on the outcome of immune checkpoint inhibitors.

de Joode K et al.

Cancer Treatment Reviews, 2024

Association between CTLA4 + 49A/G polymorphism and risk of hepatocellular carcinoma: a systematic review and meta-analysis.

Tan X et al.

Nucleosides, Nucleotides & Nucleic Acids, 2024

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."