Associated Papers
The ubiquitin ligase HUWE1 enhances WNT signaling by antagonizing destruction complex-mediated β-catenin degradation and through a mechanism independent of changes in β-catenin abundance.
McKenna JK et al.
Plos Genetics, 2025
Pilomatrix-like High-grade Endometrial Carcinoma: An Underdiagnosed Entity With Aggressive Clinicopathologic Features.
Zhou F et al.
The American Journal of Surgical Pathology, 2025
Molecular characterization of archival adrenal tumor tissue from patients with ACTH-independent Cushing syndrome.
Rege J et al.
The Journal of Steroid Biochemistry and Molecular Biology, 2025
Wilms tumor primary cultures capture phenotypic heterogeneity and facilitate preclinical screening.
Götz L et al.
Translational Oncology, 2025
Whole-exome sequencing reveals genomic landscape of intrahepatic cholangiocarcinoma and identifies SAV1 as a potential driver.
Zhou ZJ et al.
Nature Communications, 2024
Molecular Analysis of Renal/Adrenal Angiosarcomas Reveals High Frequency of Recurrent Genetic Alterations.
Argani P et al.
Genes, Chromosomes & Cancer, 2024
Phospholipid isotope tracing suggests β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma.
VanSant-Webb C et al.
Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids, 2024
Targeted Next Generation Sequencing molecular profiling and its clinical application in adrenocortical cancer.
Cioppi F et al.
European Journal of Endocrinology, 2024
Semaphorin Receptors Antagonize Wnt Signaling Through Beta-Catenin Degradation.
Hoard TM et al.
Biorxiv : the Preprint Server for Biology, 2024
Pharmacogenomic profiling of intra-tumor heterogeneity using a large organoid biobank of liver cancer.
Yang H et al.
Cancer Cell, 2024
Targeted next-generation sequencing of 491 lung cancers in clinical practice: Implications for future detection strategy and targeted therapy.
Liu XD et al.
Heliyon, 2024
Oncogenic β-catenin-driven liver cancer is susceptible to methotrexate-mediated disruption of nucleotide synthesis.
Liu F et al.
Chinese Medical Journal, 2024
Detection of driver mutations and genomic signatures in endometrial cancers using artificial intelligence algorithms.
Stan A et al.
Plos One, 2024
CHB patients with rtA181T-mutated HBV infection are associated with higher risk hepatocellular carcinoma due to increases in mutation rates of tumour suppressor genes.
Ning Q et al.
Journal of Viral Hepatitis, 2023
RACK1 facilitates breast cancer progression by competitively inhibiting the binding of β-catenin to PSMD2 and enhancing the stability of β-catenin.
Tian R et al.
Cell Death & Disease, 2023
Standing in the canine precision medicine knowledge gap: Improving annotation of canine cancer genomic biomarkers through systematic comparative analysis of human cancer mutations in COSMIC.
Sakthikumar S et al.
Veterinary and Comparative Oncology, 2023
Protein Tyrosine Phosphatase Non-Receptor 11 (PTPN11/Shp2) as a Driver Oncogene and a Novel Therapeutic Target in Non-Small Cell Lung Cancer (NSCLC).
Richards CE et al.
International Journal of Molecular Sciences, 2023
Noncanonical β-catenin interactions promote leukemia-initiating activity in early T-cell acute lymphoblastic leukemia.
Panelli P et al.
Blood, 2023
TROP2 Represents a Negative Prognostic Factor in Colorectal Adenocarcinoma and Its Expression Is Associated with Features of Epithelial-Mesenchymal Transition and Invasiveness.
Švec J et al.
Cancers, 2022
Biclonal Desmoid-Type Fibromatosis With Two Beta-Catenin Mutations: Evidence for the Recruitment of Normal Myofibroblasts.
Skubitz KM et al.
Cureus, 2022
Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways.
Lavoie JM et al.
Cold Spring Harbor Molecular Case Studies, 2022
Targeted Mutational Analysis of Cortisol-Producing Adenomas.
Rege J et al.
The Journal of Clinical Endocrinology and Metabolism, 2022
Aberrant Expression and Subcellular Localization of ECT2 Drives Colorectal Cancer Progression and Growth.
Cook DR et al.
Cancer Research, 2022
Phosphorylation of β-catenin Ser60 by polo-like kinase 1 drives the completion of cytokinesis.
Yu JE et al.
Embo Reports, 2021
Somatic mutations of GNA11 and GNAQ in CTNNB1-mutant aldosterone-producing adenomas presenting in puberty, pregnancy or menopause.
Zhou J et al.
Nature Genetics, 2021
Intrinsic activation of β-catenin signaling by CRISPR/Cas9-mediated exon skipping contributes to immune evasion in hepatocellular carcinoma.
Akasu M et al.
Scientific Reports, 2021
Exploring the Interplay of Telomerase Reverse Transcriptase and β-Catenin in Hepatocellular Carcinoma.
Kotiyal S et al.
Cancers, 2021
Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture, phosphorylation, and ubiquitylation.
Ranes M et al.
Molecular Cell, 2021
Mutation profile and immunoscore signature in thymic carcinomas: An exploratory study and review of the literature.
Asselta R et al.
Thoracic Cancer, 2021
Reconciling the Biological and Transcriptional Variability of Hepatoblastoma with Its Mutational Uniformity.
Prochownik EV
Cancers, 2021
Primary Cilia Formation Does Not Rely on WNT/β-Catenin Signaling.
Bernatik O et al.
Frontiers in Cell and Developmental Biology, 2021
Case Report: Consecutive Adrenal Cushing's Syndrome and Cushing's Disease in a Patient With Somatic CTNNB1, USP8, and NR3C1 Mutations.
Detomas M et al.
Frontiers in Endocrinology, 2021
Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis.
Hescheler DA et al.
Frontiers in Endocrinology, 2021
The Genomic Landscape of Serrated Lesion of the Colorectum: Similarities and Differences With Tubular and Tubulovillous Adenomas.
Tornillo L et al.
Frontiers in Oncology, 2021
Comprehensive Biology and Genetics Compendium of Wilms Tumor Cell Lines with Different WT1 Mutations.
Royer-Pokora B et al.
Cancers, 2020
Expression of transgenes enriched in rare codons is enhanced by the MAPK pathway.
Peterson J et al.
Scientific Reports, 2020
Multivalent tumor suppressor adenomatous polyposis coli promotes Axin biomolecular condensate formation and efficient β-catenin degradation.
Li TM et al.
Scientific Reports, 2020
Integrated genomic analysis reveals mutated ELF3 as a potential gallbladder cancer vaccine candidate.
Pandey A et al.
Nature Communications, 2020
An Activating Variant in CTNNB1 is Associated with a Sclerosing Bone Dysplasia and Adrenocortical Neoplasia.
Peng H et al.
The Journal of Clinical Endocrinology and Metabolism, 2020
IPO11 mediates βcatenin nuclear import in a subset of colorectal cancers.
Mis M et al.
The Journal of Cell Biology, 2020
Broad regulation of gene isoform expression by Wnt signaling in cancer.
Idris M et al.
Rna (new York, N.y.), 2019