Varaico: Literature-Extracted Genetic Variants

Gene:CTNNB1
Variant:p.V600E
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CTNNB1

NM_001904.4:p.V600E

Associated Papers

Intrauterine-diagnosed fetal intracranial adamantinomatous craniopharyngioma: A case report with histopathological and molecular characterization.

Pena-Burgos EM et al.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics, 2026

A prospective, multicenter, comprehensive genomic profile signature study in patients with EGFR-mutant advanced non-small cell lung cancer at the first-line treatment failure of osimertinib.

Shi Y et al.

Signal Transduction and Targeted Therapy, 2025

41326340 (PubMed )
Supplement: 41392_2025_2481_MOESM1_ESM.docx

Relationship between melanoma vemurafenib tolerance thresholds and metabolic pathway choice and Wnt signaling involvement.

Nangia-Makker P et al.

Biorxiv : the Preprint Server for Biology, 2025

Small Molecule B-RAF Inhibitors as Anti-Cancer Therapeutics: Advances in Discovery, Development, and Mechanistic Insights.

Anaya YA et al.

International Journal of Molecular Sciences, 2025

Next-Generation Sequencing (NGS) in non-small cell lung carcinoma: A real-world experience in the public health system of Galicia (Northwest Spain).

Abdulkader-Nallib I et al.

Plos One, 2025

Analytical and clinical validation of a NGS panel in detecting targetable variants from ctDNA of metastatic NSCLC patients.

Fan F et al.

Cancer Medicine, 2024

39385536 (PubMed )
Supplement: CAM4-13-e70078-s001.docx

Lack of shared neoantigens in prevalent mutations in cancer.

Ragone C et al.

Journal of Translational Medicine, 2024

Baseline mutational profiles of patients with carcinoma of unknown primary origin enrolled in the CUPISCO study.

Westphalen CB et al.

Esmo Open, 2023

37922692 (PubMed )
Supplement: mmc1.docx

Apolipoprotein E2 Stimulates Protein Synthesis and Promotes Melanoma Progression and Metastasis.

Adaku N et al.

Cancer Research, 2023

One-step generation of tumor models by base editor multiplexing in adult stem cell-derived organoids.

Geurts MH et al.

Nature Communications, 2023

Landscape of Genetic Mutations in Appendiceal Cancers.

Constantin M et al.

Cancers, 2023

Histological and Genetic Diversity in Ovarian Mucinous Carcinomas: A Pilot Study.

Razia S et al.

Current Oncology (toronto, Ont.), 2023

Genetic landscape and personalized tracking of tumor mutations in Vietnamese women with breast cancer.

Nguyen Hoang VA et al.

Molecular Oncology, 2023

36495126 (PubMed )
Supplement: MOL2-17-598-s001.docx

Coincidence of primary adrenocortical carcinoma and melanoma: three CASE reports.

Ko YL et al.

Bmc Endocrine Disorders, 2023

Multigene Panel Sequencing Reveals Cancer-Specific and Common Somatic Mutations in Colorectal Cancer Patients: An Egyptian Experience.

Youssef ASE et al.

Current Issues in Molecular Biology, 2022

Encorafenib plus cetuximab for the treatment of BRAF-V600E-mutated metastatic colorectal cancer.

Ros J et al.

Therapeutic Advances in Gastroenterology, 2022

CTNNB1 mutations in papillary thyroid carcinoma with prominent myofibroblastic stromal component.

Roukain A et al.

Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc, 2021

RTK Inhibitors in Melanoma: From Bench to Bedside.

Sabbah M et al.

Cancers, 2021

Combination of Congenital and Deep Penetrating Nevus by Acquisition of β-Catenin Activation.

Garrido MC et al.

The American Journal of Dermatopathology, 2020

Spectrum of driver mutations and clinical impact of circulating tumor DNA analysis in non-small cell lung cancer: Analysis of over 8000 cases.

Mack PC et al.

Cancer, 2020

32365229 (PubMed )
Supplement: CNCR-126-3219-s002.docx

Rapid clinical mutational testing of KRAS, BRAF and EGFR: a prospective comparative analysis of the Idylla technique with high-throughput next-generation sequencing.

Van Haele M et al.

Journal of Clinical Pathology, 2020

The most common RNF43 mutant G659Vfs*41 is fully functional in inhibiting Wnt signaling and unlikely to play a role in tumorigenesis.

Tu J et al.

Scientific Reports, 2019

31811196 (PubMed )
Supplement: 41598_2019_54931_MOESM1_ESM.pdf

Role of miR-214 in regulation of β-catenin and the malignant phenotype of melanoma.

Prabhakar K et al.

Molecular Carcinogenesis, 2019

SOX11 expression in a case of papillary thyroid carcinoma with fibromatosis/fasciitis-like stroma containing BRAF c.1799_1801delTGA and CTNNB1 c.133T>C mutations.

Wong SBJ et al.

Virchows Archiv : an International Journal of Pathology, 2019

Negative Regulation of p53-Induced Senescence by N-WASP Is Crucial for DMBA/TPA-Induced Skin Tumor Formation.

Li H et al.

Cancer Research, 2019

Biomarker results from a phase II study of MEK1/2 inhibitor binimetinib (MEK162) in patients with advanced NRAS- or BRAF-mutated melanoma.

van Herpen CML et al.

Oncotarget, 2019

30956763 (PubMed )
Supplement: oncotarget-10-1850-s001.pdf

Targeted Sequencing Analysis of Pulmonary Adenocarcinoma with Multiple Synchronous Ground-Glass/Lepidic Nodules.

Park E et al.

Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer, 2018

Comprehensive molecular characterisation of epilepsy-associated glioneuronal tumours.

Stone TJ et al.

Acta Neuropathologica, 2018

Mutational profiling of acral melanomas in Korean populations.

Shim JH et al.

Experimental Dermatology, 2017

Induction of immunoglobulin transcription factor 2 and resistance to MEK inhibitor in melanoma cells.

Hur EH et al.

Oncotarget, 2017

Prevalence and coexistence of KRAS, BRAF, PIK3CA, NRAS, TP53, and APC mutations in Indian colorectal cancer patients: Next-generation sequencing-based cohort study.

Jauhri M et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2017

Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway.

Sakai E et al.

International Journal of Cancer, 2016

26510091 (PubMed )
Supplement: IJC-138-1634-s001.pdf

Genome-wide linkage analysis and tumoral characterization reveal heterogeneity in familial colorectal cancer type X.

Sánchez-Tomé E et al.

Journal of Gastroenterology, 2015

MicroRNA expression in BRAF-mutated and wild-type metastatic melanoma and its correlation with response duration to BRAF inhibitors.

Pinto R et al.

Expert Opinion on Therapeutic Targets, 2015

Exome sequencing identifies BRAF mutations in papillary craniopharyngiomas.

Brastianos PK et al.

Nature Genetics, 2014

24413733 (PubMed )
Supplement: NIHMS547859-supplement-1.xlsx › Supplementary_Table_4

Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.

Griewank KG et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2013

Geographic analysis of RKIP expression and its clinical relevance in colorectal cancer.

Koelzer VH et al.

British Journal of Cancer, 2013

Germline mutations affecting the proofreading domains of POLE and POLD1 predispose to colorectal adenomas and carcinomas.

Palles C et al.

Nature Genetics, 2013

23263490 (PubMed )
Supplement: NIHMS53122-supplement-1.pdf

MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling.

Cha YH et al.

Cell Cycle (georgetown, Tex.), 2012

Thyroid cancer cell lines: an overview.

Saiselet M et al.

Frontiers in Endocrinology, 2012

Exome sequencing identifies recurrent somatic MAP2K1 and MAP2K2 mutations in melanoma.

Nikolaev SI et al.

Nature Genetics, 2011

Molecular profiling of melanoma and the evolution of patient-specific therapy.

Gajewski TF

Seminars in Oncology, 2011

Sessile serrated adenoma with early neoplastic progression: a clinicopathologic and molecular study.

Fujita K et al.

The American Journal of Surgical Pathology, 2011

Structure and regulation of the versican promoter: the versican promoter is regulated by AP-1 and TCF transcription factors in invasive human melanoma cells.

Domenzain-Reyna C et al.

The Journal of Biological Chemistry, 2009

Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma.

Lee JJ et al.

Endocrine-related Cancer, 2008

Ampullary carcinoma-A genetic perspective.

Jayaramayya K et al.

Mutation Research. Reviews in Mutation Research, 0

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