Varaico: Literature-Extracted Genetic Variants

Gene:CTTN
Variant:p.Y421F
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CTTN

NM_005231.4:p.Y421F

Associated Papers

MenaINV dysregulates cortactin phosphorylation to promote invadopodium maturation.

Weidmann MD et al.

Scientific Reports, 2016

The Microtubule Plus End Tracking Protein TIP150 Interacts with Cortactin to Steer Directional Cell Migration.

Adams G et al.

The Journal of Biological Chemistry, 2016

RPTPα controls epithelial adherens junctions, linking E-cadherin engagement to c-Src-mediated phosphorylation of cortactin.

Truffi M et al.

Journal of Cell Science, 2014

Src binds cortactin through an SH2 domain cystine-mediated linkage.

Evans JV et al.

Journal of Cell Science, 2012

Cortactin phosphorylated by ERK1/2 localizes to sites of dynamic actin regulation and is required for carcinoma lamellipodia persistence.

Kelley LC et al.

Plos One, 2010

Specific tyrosine phosphorylation sites on cortactin regulate Nck1-dependent actin polymerization in invadopodia.

Oser M et al.

Journal of Cell Science, 2010

Arg interacts with cortactin to promote adhesion-dependent cell edge protrusion.

Lapetina S et al.

The Journal of Cell Biology, 2009

Centrosome separation driven by actin-microfilaments during mitosis is mediated by centrosome-associated tyrosine-phosphorylated cortactin.

Wang W et al.

Journal of Cell Science, 2008

Receptor-mediated endocytosis involves tyrosine phosphorylation of cortactin.

Zhu J et al.

The Journal of Biological Chemistry, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."