Varaico: Literature-Extracted Genetic Variants

Gene:CUL2
Variant:p.K689R
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CUL2

NM_003591.4:p.K689R

Associated Papers

Inactivating UBE2M impacts the DNA damage response and genome integrity involving multiple cullin ligases.

Cukras S et al.

Plos One, 2014

UBXN7 docks on neddylated cullin complexes using its UIM motif and causes HIF1α accumulation.

Bandau S et al.

Bmc Biology, 2012

NEDD8 links cullin-RING ubiquitin ligase function to the p97 pathway.

den Besten W et al.

Nature Structural & Molecular Biology, 2012

The von Hippel-Lindau tumor suppressor gene product promotes, but is not essential for, NEDD8 conjugation to cullin-2.

Wada H et al.

The Journal of Biological Chemistry, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."