Associated Papers
Cryo-EM structure of monomeric CXCL12-bound CXCR4 in the active state.
Liu Y et al.
Cell Reports, 2024
Functional anatomy of the full-length CXCR4-CXCL12 complex systematically dissected by quantitative model-guided mutagenesis.
Stephens BS et al.
Science Signaling, 2020
Probing the Molecular Interactions between CXC Chemokine Receptor 4 (CXCR4) and an Arginine-Based Tripeptidomimetic Antagonist (KRH-1636).
Zachariassen ZG et al.
Journal of Medicinal Chemistry, 2015
Determination of the binding mode for the cyclopentapeptide CXCR4 antagonist FC131 using a dual approach of ligand modifications and receptor mutagenesis.
Thiele S et al.
British Journal of Pharmacology, 2014
Distinct functional sites for human immunodeficiency virus type 1 and stromal cell-derived factor 1alpha on CXCR4 transmembrane helical domains.
Tian S et al.
Journal of Virology, 2005
Identification of residues of CXCR4 critical for human immunodeficiency virus coreceptor and chemokine receptor activities.
Brelot A et al.
The Journal of Biological Chemistry, 2000
Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry.
Chabot DJ et al.
The Journal of Biological Chemistry, 2000
Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates.
Chabot DJ et al.
Journal of Virology, 1999
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