Varaico: Literature-Extracted Genetic Variants

Gene:CYP1A1
Variant:p.T461N
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CYP1A1

NM_001319217.2:p.T461N

Associated Papers

Natural Polymorphic Variants in the CYP450 Superfamily: A Review of Potential Structural Mechanisms and Functional Consequences.

Prost R et al.

International Journal of Molecular Sciences, 2025

Human Cytochrome P450 Cancer-Related Metabolic Activities and Gene Polymorphisms: A Review.

Mokhosoev IM et al.

Cells, 2024

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Meta-Analysis of 49 SNPs Covering 25,446 Cases and 41,106 Controls Identifies Polymorphisms in Hormone Regulation and DNA Repair Genes Associated with Increased Endometrial Cancer Risk.

Das AP et al.

Genes, 2023

36981012 (PubMed )
Supplement: genes-14-00741-s001.zip › Table_S1.xlsx › Table_S1

Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles.

Chamboko CR et al.

International Journal of Molecular Sciences, 2023

36834793 (PubMed )
Supplement: ijms-24-03383-s001.zip › ijms-2130595-supplementary.pdf

A review on the genetic polymorphisms and susceptibility of cancer patients in Bangladesh.

Babu G et al.

Molecular Biology Reports, 2022

Polymorphisms in PAH metabolising enzyme CYP1A1 in colorectal cancer and their clinicopathological correlations.

Cheng T et al.

Pathology, Research and Practice, 2022

Gene polymorphisms and risk of head and neck squamous cell carcinoma: a systematic review.

Rajabi-Moghaddam M et al.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 2022

Currently favored sampling practices for tumor sequencing can produce optimal results in the clinical setting.

Pongor LS et al.

Scientific Reports, 2020

32873813 (PubMed )
Supplement: 41598_2020_71382_MOESM6_ESM.xlsx › Hypermutating

Steroid hormone-related polymorphisms associate with the development of bone erosions in rheumatoid arthritis and help to predict disease progression: Results from the REPAIR consortium.

Sánchez-Maldonado JM et al.

Scientific Reports, 2019

Polymorphisms at phase I-metabolizing enzyme and hormone receptor loci influence the response to anti-TNF therapy in rheumatoid arthritis patients.

Canet LM et al.

The Pharmacogenomics Journal, 2019

Incidence of Mutations in the ALPL, GGPS1, and CYP1A1 Genes in Patients With Atypical Femoral Fractures.

Peris P et al.

Jbmr Plus, 2019

Genetic predisposition to lung cancer: comprehensive literature integration, meta-analysis, and multiple evidence assessment of candidate-gene association studies.

Wang J et al.

Scientific Reports, 2017

28827732 (PubMed )
Supplement: 41598_2017_7737_MOESM1_ESM.pdf

Association of CYP1A1 and CYP1B1 polymorphisms with bone mineral density variations in postmenopausal Mexican-Mestizo women.

Chávez B et al.

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology, 2017

Genetic polymorphisms of human cytochrome P450 CYP1A1 in an Egyptian population and tobacco-induced lung cancer.

Ezzeldin N et al.

Genes and Environment : the Official Journal of the Japanese Environmental Mutagen Society, 2017

Association of oxidative stress gene polymorphisms with presbycusis.

Manche SK et al.

Gene, 2016

Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy.

Lewis BC et al.

Pharmacogenetics and Genomics, 2016

Lack of Association between CYP1A1 M2 and M4 Polymorphisms and Breast Carcinoma in Jordanian Women: a Case-Control Study.

Amrani I et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2016

Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach.

Karageorgos I et al.

Human Genomics, 2015

26092435 (PubMed )
Supplement: 40246_2015_34_MOESM1_ESM.xlsx › FamilyA

The GSTM1null (deletion) and MGMT84 rs12917 (Phe/Phe) haplotype are associated with bulky DNA adduct levels in human leukocytes.

Molina E et al.

Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2013

Association of CYP1A1 gene polymorphism with chronic kidney disease: a case control study.

Siddarth M et al.

Environmental Toxicology and Pharmacology, 2013

Lung cancer risk in relation to nicotinic acetylcholine receptor, CYP2A6 and CYP1A1 genotypes in the Bangladeshi population.

Islam MS et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2013

Polymorphisms in the human cytochrome P450 and arylamine N-acetyltransferase: susceptibility to head and neck cancers.

Khlifi R et al.

Biomed Research International, 2013

Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and ovarian cancer risk: a meta-analysis.

Sergentanis TN et al.

Molecular Biology Reports, 2012

Cytochrome P450 1A1 (CYP1A1) gene polymorphisms and cervical cancer risk: a meta-analysis.

Sergentanis TN et al.

Molecular Biology Reports, 2012

Estrogen-related genes and their contribution to racial differences in breast cancer risk.

Reding KW et al.

Cancer Causes & Control : Ccc, 2012

Heterocyclic aromatic amine [HCA] intake and prostate cancer risk: effect modification by genetic variants.

Van Hemelrijck M et al.

Nutrition and Cancer, 2012

Polymorphisms in miRNA binding site: new insight into small cell lung cancer susceptibility.

Liu HY et al.

Acta Pharmacologica Sinica, 2011

Polymorphisms associated with the risk of lung cancer in a healthy Mexican Mestizo population: Application of the additive model for cancer.

Pérez-Morales R et al.

Genetics and Molecular Biology, 2011

CYP1A1, CYP3A5 and CYP3A7 polymorphisms and testicular cancer susceptibility.

Kristiansen W et al.

International Journal of Andrology, 2011

Genetic variation in the bioactivation pathway for polycyclic hydrocarbons and heterocyclic amines in relation to risk of colorectal neoplasia.

Wang H et al.

Carcinogenesis, 2011

Cytochrome P450 1A1 gene polymorphisms and endometrial cancer risk: a meta-analysis.

Sergentanis TN et al.

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society, 2011

Inhibition of 17β-estradiol activation by CYP1A1: genotype- and regioselective inhibition by St. John's Wort and several natural polyphenols.

Schwarz D et al.

Biochimica Et Biophysica Acta, 2011

Genetic variability in estrogen disposition: Potential clinical implications for neuropsychiatric disorders.

Grover S et al.

American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2010

Association of human cytochrome P450 1A1 (CYP1A1) and sulfotransferase 1A1 (SULT1A1) polymorphisms with differential metabolism and cytotoxicity of aminoflavone.

Zheng Q et al.

Molecular Cancer Therapeutics, 2010

Smoking related risk involved in individuals carrying genetic variants of CYP1A1 gene in head and neck cancer.

Sabitha K et al.

Cancer Epidemiology, 2010

CYP1A1 gene polymorphisms increase lung cancer risk in a high-incidence region of Spain: a case control study.

San Jose C et al.

Bmc Cancer, 2010

Microarray-based detection of CYP1A1, CYP2C9, CYP2C19, CYP2D6, GSTT1, GSTM1, MTHFR, MTRR, NQO1, NAT2, HLA-DQA1, and AB0 allele frequencies in native Russians.

Gra O et al.

Genetic Testing and Molecular Biomarkers, 2010

Genetic association study of CYP1A1 polymorphisms identifies risk haplotypes in nonsmall cell lung cancer.

Wright CM et al.

The European Respiratory Journal, 2010

Novel pathway analysis of genomic polymorphism-cancer risk interaction in the Breast Cancer Prevention Trial.

Dunn BK et al.

International Journal of Molecular Epidemiology and Genetics, 2010

Risk of malignant pleural mesothelioma and polymorphisms in genes involved in the genome stability and xenobiotics metabolism.

Gemignani F et al.

Mutation Research, 2009

Aromatic DNA adducts and polymorphisms in metabolic genes in healthy adults: findings from the EPIC-Spain cohort.

Agudo A et al.

Carcinogenesis, 2009

Polymorphisms of Metabolizing Enzymes and Susceptibility to Ethmoid Intestinal-type Adenocarcinoma in Professionally Exposed Patients.

Pastore E et al.

Translational Oncology, 2009

The Val432Leu polymorphism of the CYP1B1 gene is associated with differences in estrogen metabolism and bone density.

Napoli N et al.

Bone, 2009

Bladder cancer risk and genetic variation in AKR1C3 and other metabolizing genes.

Figueroa JD et al.

Carcinogenesis, 2008

Genetic variation in genes for the xenobiotic-metabolizing enzymes CYP1A1, EPHX1, GSTM1, GSTT1, and GSTP1 and susceptibility to colorectal cancer in Lynch syndrome.

Pande M et al.

Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology, 2008

CYP1A1 and CYP1B1 genetic polymorphisms and uterine leiomyoma risk in Chinese women.

Ye Y et al.

Journal of Assisted Reproduction and Genetics, 2008

A comprehensive analysis of phase I and phase II metabolism gene polymorphisms and risk of non-small cell lung cancer in smokers.

Zienolddiny S et al.

Carcinogenesis, 2008

Cytochrome P450 1A1, cigarette smoking, and risk of endometrial cancer (United States).

McGrath M et al.

Cancer Causes & Control : Ccc, 2007

CYP1A1 and CYP1B1 genetic polymorphisms, smoking and breast cancer risk in a Finnish Caucasian population.

Sillanpää P et al.

Breast Cancer Research and Treatment, 2007

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."