Varaico: Literature-Extracted Genetic Variants

Gene:CYP1A2
Variant:p.R243R
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CYP1A2

NM_000761.5:p.R243R

Associated Papers

GenoStaR: An R Package for Genotype to Star Allele Conversion for Major Cytochrome P450 Family of Genes.

Coulter AJ et al.

Clinical Pharmacology and Therapeutics, 2026

CYP1A2 expression and activity in a large panel of human nonneoplastic surgical liver samples: Influence of genetics, lifestyle, and other factors.

Kuhn UD et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2025

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Genetic Biomarkers of Antipsychotic-Induced Prolongation of the QT Interval in Patients with Schizophrenia.

Vaiman EE et al.

International Journal of Molecular Sciences, 2022

CYP1A2 mRNA Expression Rather than Genetic Variants Indicate Hepatic CYP1A2 Activity.

Fekete F et al.

Pharmaceutics, 2022

Relationships between CYP1A2, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 metabolic phenotypes and genotypes in a Nicaraguan Mestizo population.

de Andrés F et al.

The Pharmacogenomics Journal, 2021

A review of the existing literature on buprenorphine pharmacogenomics.

Meaden CW et al.

The Pharmacogenomics Journal, 2021

Pharmacogene Variation in Thai Plasmodium vivax Relapse Patients Treated with a Combination of Primaquine and Chloroquine.

Chamnanphon M et al.

Pharmacogenomics and Personalized Medicine, 2020

Impact of CYP1A2 genetic polymorphisms on pharmacokinetics of antipsychotic drugs: a systematic review and meta-analysis.

Na Takuathung M et al.

Acta Psychiatrica Scandinavica, 2019

Clinical Implementation of Pharmacogenetic Decision Support Tools for Antidepressant Drug Prescribing.

Zeier Z et al.

The American Journal of Psychiatry, 2018

Pharmacogenetic analysis of opioid dependence treatment dose and dropout rate.

Crist RC et al.

The American Journal of Drug and Alcohol Abuse, 2018

CYP1A2 Genotype Variations Do Not Modify the Benefits and Drawbacks of Caffeine during Exercise: A Pilot Study.

Salinero JJ et al.

Nutrients, 2017

Characterization of ADME gene variation in 21 populations by exome sequencing.

Hovelson DH et al.

Pharmacogenetics and Genomics, 2017

27984508 (PubMed )
Supplement: fpc-27-089-s004.xlsx › CorePharmADME.VariantDepthStats

Palpitations and Asthenia Associated with Venlafaxine in a CYP2D6 Poor Metabolizer and CYP2C19 Intermediate Metabolizer.

Garcia S et al.

Case Reports in Genetics, 2017

Genetic polymorphism analysis of the drug-metabolizing enzyme CYP1A2 in a Uyghur Chinese population: a pilot study.

Geng T et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2016

Use of combinatorial pharmacogenomic testing in two cases from community psychiatry.

Fields ES et al.

Pharmacogenomics and Personalized Medicine, 2016

Clinical validity: Combinatorial pharmacogenomics predicts antidepressant responses and healthcare utilizations better than single gene phenotypes.

Altar CA et al.

The Pharmacogenomics Journal, 2015

Genetic and Clinical Factors Affecting Plasma Clozapine Concentration.

Olsson E et al.

The Primary Care Companion for Cns Disorders, 2015

Genetic polymorphisms in promoter and intronic regions of CYP1A2 gene in Roma and Hungarian population samples.

Szalai R et al.

Environmental Toxicology and Pharmacology, 2014

Induction of CYP1A2 by heavy coffee consumption is associated with the CYP1A2 -163C>A polymorphism.

Djordjevic N et al.

European Journal of Clinical Pharmacology, 2010

Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.

Zhou SF et al.

Drug Metabolism Reviews, 2010

Pazopanib-induced hyperbilirubinemia is associated with Gilbert's syndrome UGT1A1 polymorphism.

Xu CF et al.

British Journal of Cancer, 2010

Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2.

Zhou SF et al.

The Aaps Journal, 2009

Allele-specific expression and gene methylation in the control of CYP1A2 mRNA level in human livers.

Ghotbi R et al.

The Pharmacogenomics Journal, 2009

Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population.

Gunes A et al.

Pharmacogenomics, 2009

Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects.

Ingelman-Sundberg M et al.

Pharmacology & Therapeutics, 2007

Comparisons of CYP1A2 genetic polymorphisms, enzyme activity and the genotype-phenotype relationship in Swedes and Koreans.

Ghotbi R et al.

European Journal of Clinical Pharmacology, 2007

Investigating the phenotypes and genotypes of breast cancer in women with African ancestry: the need for more genetic epidemiology.

Hayanga AJ et al.

The Surgical Clinics of North America, 2007

Phenotype-genotype analysis of CYP1A2 in Japanese patients receiving oral theophylline therapy.

Takata K et al.

European Journal of Clinical Pharmacology, 2006

Functional analysis of three CYP1A2 variants found in a Japanese population.

Saito Y et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2005

Polymorphisms affecting gene regulation and mRNA processing: broad implications for pharmacogenetics.

Johnson AD et al.

Pharmacology & Therapeutics, 2005

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."