Varaico: Literature-Extracted Genetic Variants

Gene:CYP1A2
Variant:p.L382V
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CYP1A2

NM_000761.5:p.L382V

Associated Papers

Increased Phenacetin Oxidation upon the L382V Substitution in Cytochrome P450 1A2 is Associated with Altered Substrate Binding Orientation.

Huang Q et al.

International Journal of Molecular Sciences, 2018

Human cytochrome P450 1A1 structure and utility in understanding drug and xenobiotic metabolism.

Walsh AA et al.

The Journal of Biological Chemistry, 2013

Significant increase in phenacetin oxidation on L382V substitution in human cytochrome P450 1A2.

Huang Q et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2010

Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.

Zhou SF et al.

Drug Metabolism Reviews, 2010

Adaptations for the oxidation of polycyclic aromatic hydrocarbons exhibited by the structure of human P450 1A2.

Sansen S et al.

The Journal of Biological Chemistry, 2007

The effect of reciprocal active site mutations in human cytochromes P450 1A1 and 1A2 on alkoxyresorufin metabolism.

Liu J et al.

Archives of Biochemistry and Biophysics, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."