Associated Papers
Natural Polymorphic Variants in the CYP450 Superfamily: A Review of Potential Structural Mechanisms and Functional Consequences.
Prost R et al.
International Journal of Molecular Sciences, 2025
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y et al.
The Pharmacogenomics Journal, 2024
Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.
Zhang T et al.
Peerj, 2024
Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles.
Chamboko CR et al.
International Journal of Molecular Sciences, 2023
Comparison of genetic susceptibility to lung adenocarcinoma and squamous cell carcinoma in Japanese patients using a novel panel for cancer-related drug-metabolizing enzyme genes.
Ohnami S et al.
Scientific Reports, 2022
Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data.
Neyshaburinezhad N et al.
Journal of Personalized Medicine, 2021
Functional Characterization of 21 Rare Allelic CYP1A2 Variants Identified in a Population of 4773 Japanese Individuals by Assessing Phenacetin O-Deethylation.
Kumondai M et al.
Journal of Personalized Medicine, 2021
In silico screening and analysis of nonsynonymous SNPs in human CYP1A2 to assess possible associations with pathogenicity and cancer susceptibility.
Navapour L et al.
Scientific Reports, 2021
Impact of peripheral mutations on the access channels of human cytochrome P450 1A2.
Ying B et al.
Journal of Biomolecular Structure & Dynamics, 2020
An optimized prediction framework to assess the functional impact of pharmacogenetic variants.
Zhou Y et al.
The Pharmacogenomics Journal, 2019
Impaired dacarbazine activation and 7-ethoxyresorufin deethylation in vitro by polymorphic variants of CYP1A1 and CYP1A2: implications for cancer therapy.
Lewis BC et al.
Pharmacogenetics and Genomics, 2016
Cytochrome P450 expression system for high-throughput real-time detection of genotoxicity: Application to the study of human CYP1A2 variants.
Palma BB et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2016
Prediction of three-dimensional structures and structural flexibilities of wild-type and mutant cytochrome P450 1A2 using molecular dynamics simulations.
Watanabe Y et al.
Journal of Molecular Graphics & Modelling, 2016
Functional characterization of 20 allelic variants of CYP1A2.
Ito M et al.
Drug Metabolism and Pharmacokinetics, 2015
Functional Significance of Cytochrome P450 1A2 Allelic Variants, P450 1A2*8, *15, and *16 (R456H, P42R, and R377Q).
Lim YR et al.
Biomolecules & Therapeutics, 2015
Activation of aflatoxin B1 by expression of human CYP1A2 polymorphisms in Saccharomyces cerevisiae.
Fasullo M et al.
Mutation Research. Genetic Toxicology and Environmental Mutagenesis, 2014
Functional characterization of eight human CYP1A2 variants: the role of cytochrome b5.
Palma BB et al.
Pharmacogenetics and Genomics, 2013
Polymorphic metabolism by functional alterations of human cytochrome P450 enzymes.
Lee IS et al.
Archives of Pharmacal Research, 2011
Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression.
Palma BB et al.
The Pharmacogenomics Journal, 2010
Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.
Zhou SF et al.
Drug Metabolism Reviews, 2010
New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.
Wang B et al.
Drug Metabolism Reviews, 2009
A natural variant of the heme-binding signature (R441C) resulting in complete loss of function of CYP2D6.
Klein K et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2007
Functional analysis of three CYP1A2 variants found in a Japanese population.
Saito Y et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2005
Single nucleotide polymorphisms and haplotypes of CYP1A2 in a Japanese population.
Soyama A et al.
Drug Metabolism and Pharmacokinetics, 2005