Varaico: Literature-Extracted Genetic Variants

Gene:CYP2A6
Variant:p.N338S
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CYP2A6

NM_000762.6:p.N338S

Associated Papers

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Points-to-consider documents: Scientific information on the evaluation of genetic polymorphisms during non-clinical studies and phase I clinical trials in the Japanese population.

Hiratsuka M et al.

Drug Metabolism and Pharmacokinetics, 2018

Distribution of polymorphic variants of CYP2A6 and their involvement in nicotine addiction.

López-Flores LA et al.

Excli Journal, 2017

CYP2A7 pseudogene transcript affects CYP2A6 expression in human liver by acting as a decoy for miR-126.

Nakano M et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2015

CYP2A6 Polymorphisms May Strengthen Individualized Treatment for Nicotine Dependence.

Akrodou YM

Scientifica, 2015

High CYP2A6 enzyme activity as measured by a caffeine test and unique distribution of CYP2A6 variant alleles in Ethiopian population.

Aklillu E et al.

Omics : a Journal of Integrative Biology, 2014

The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans.

Bloom J et al.

Pharmacogenetics and Genomics, 2011

Associations of various gene polymorphisms with toxicity in colorectal cancer patients receiving oral uracil and tegafur plus leucovorin: a prospective study.

Tsunoda A et al.

Annals of Oncology : Official Journal of the European Society for Medical Oncology, 2011

Comparison of the pharmacokinetics and pharmacodynamics of S-1 between Caucasian and East Asian patients.

Chuah B et al.

Cancer Science, 2011

A novel CYP2A6 allele (CYP2A6*35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo.

Al Koudsi N et al.

The Pharmacogenomics Journal, 2009

Genotyping panel for assessing response to cancer chemotherapy.

Dai Z et al.

Bmc Medical Genomics, 2008

18547414 (PubMed )
Supplement: 1755-8794-1-24-S1.xls › SNPs_selected_for_SNPlex_design

Novel and established CYP2A6 alleles impair in vivo nicotine metabolism in a population of Black African descent.

Mwenifumbo JC et al.

Human Mutation, 2008

Differences in pharmacogenetics of nicotine and alcohol metabolism: review and recommendations for future research.

Wall TL et al.

Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, 2007

A novel duplication type of CYP2A6 gene in African-American population.

Fukami T et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2007

Comprehensive evaluation of variability in nicotine metabolism and CYP2A6 polymorphic alleles in four ethnic populations.

Nakajima M et al.

Clinical Pharmacology and Therapeutics, 2006

Three haplotypes associated with CYP2A6 phenotypes in Caucasians.

Haberl M et al.

Pharmacogenetics and Genomics, 2005

CYP2A6 genetic polymorphisms and correlation with smoking status in Brazilians.

Vasconcelos GM et al.

The Pharmacogenomics Journal, 2005

Polymorphic NF-Y dependent regulation of human nicotine C-oxidase (CYP2A6).

von Richter O et al.

Pharmacogenetics, 2004

A nicotine C-oxidase gene (CYP2A6) polymorphism important for promoter activity.

Pitarque M et al.

Human Mutation, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."