Associated Papers
Natural Polymorphic Variants in the CYP450 Superfamily: A Review of Potential Structural Mechanisms and Functional Consequences.
Prost R et al.
International Journal of Molecular Sciences, 2025
The Influence of CYP2B6, GSTP1, and SLCO1B1 Star Allele-Predicted Phenotypes and CBR1 Genetic Variants on Effectiveness Outcomes in Patients With Hepatocellular Carcinoma Receiving Doxorubicin via Transarterial Chemoembolization.
Shilbayeh SAR et al.
Pharmacology Research & Perspectives, 2025
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y et al.
The Pharmacogenomics Journal, 2024
The polygenic implication of clopidogrel responsiveness: Insights from platelet reactivity analysis and next-generation sequencing.
Echeverría O et al.
Plos One, 2024
Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.
Zhang T et al.
Peerj, 2024
Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site.
Angle ED et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2023
The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data.
Zhou Y et al.
The Pharmacogenomics Journal, 2022
Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.
Lanillos J et al.
Npj Genomic Medicine, 2022
Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.
Kim B et al.
Translational and Clinical Pharmacology, 2021
Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data.
Neyshaburinezhad N et al.
Journal of Personalized Medicine, 2021
Physiologically Based Pharmacokinetic Modeling of Bupropion and Its Metabolites in a CYP2B6 Drug-Drug-Gene Interaction Network.
Marok FZ et al.
Pharmaceutics, 2021
Allelic and genotype frequencies of major CYP2B6 polymorphisms in the Pakistani population.
Ahmed S et al.
Molecular Genetics & Genomic Medicine, 2021
Inter-ethnic genetic variations and novel variant identification in the partial sequences of CYP2B6 gene in Pakistani population.
Ahmed S et al.
Peerj, 2021
Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry.
Wang PF et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2019
The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.
Helsby NA et al.
British Journal of Clinical Pharmacology, 2019
Role of CYP2B6 pharmacogenomics in bupropion-mediated smoking cessation.
Tran AX et al.
Journal of Clinical Pharmacy and Therapeutics, 2019
EXPLORATORY ANALYSIS OF RARE AND NOVEL VARIANTS IN MEXICAN PATIENTS DIAGNOSED WITH SCHIZOPHRENIA AND DEMENTIA.
Martínez-Magaña JJ et al.
Revista De Investigacion Clinica; Organo Del Hospital De Enfermedades De La Nutricion, 2019
The Prevalence of CYP2B6 Gene Polymorphisms in Malaria-endemic Population of Timor in East Nusa Tenggara Indonesia.
Hananta L et al.
Osong Public Health and Research Perspectives, 2018
Genetic variability of CYP2D6, CYP2B6, CYP2C9 and CYP2C19 genes across the Italian Peninsula.
Carano F et al.
Annals of Human Biology, 2018
Effect of genetic polymorphism of human CYP2B6 on the metabolic activation of chlorpyrifos.
Imaishi H et al.
Pesticide Biochemistry and Physiology, 2018
Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.
Zhou Y et al.
Clinical Pharmacology and Therapeutics, 2017
Polymorphisms in cytochrome P450 oxidoreductase and its effect on drug metabolism and efficacy.
Gong L et al.
Pharmacogenetics and Genomics, 2017
Tell-Tale SNPs: The Role of CYP2B6 in Methadone Fatalities.
Ahmad T et al.
Journal of Analytical Toxicology, 2017
Standardizing terms for clinical pharmacogenetic test results: consensus terms from the Clinical Pharmacogenetics Implementation Consortium (CPIC).
Caudle KE et al.
Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2017
Polymorphisms and haplotypes of the CYP2B6 detoxification gene in the predisposition of Acute Myeloid Leukemia (AML) and induction of its cytogenetic abnormalities.
Daraki A et al.
Cancer Genetics, 2016
Insights into CYP2B6-mediated drug-drug interactions.
Hedrich WD et al.
Acta Pharmaceutica Sinica. B, 2016
Rifampin enhances cytochrome P450 (CYP) 2B6-mediated efavirenz 8-hydroxylation in healthy volunteers.
Cho DY et al.
Drug Metabolism and Pharmacokinetics, 2016
CYP2B6*6 allele and age substantially reduce steady-state ketamine clearance in chronic pain patients: impact on adverse effects.
Li Y et al.
British Journal of Clinical Pharmacology, 2015
Molecular Classification and Pharmacogenetics of Primary Plasma Cell Leukemia: An Initial Approach toward Precision Medicine.
Simeon V et al.
International Journal of Molecular Sciences, 2015
CYP2B6 gene single-nucleotide polymorphisms in an Italian population sample and relationship with nicotine dependence.
Riccardi LN et al.
Genetic Testing and Molecular Biomarkers, 2015
Whole-exome sequencing reveals overlap between macrophage activation syndrome in systemic juvenile idiopathic arthritis and familial hemophagocytic lymphohistiocytosis.
Kaufman KM et al.
Arthritis & Rheumatology (hoboken, N.j.), 2014
Pharmacogenetics of antiretroviral therapy.
Barreiro P et al.
Expert Opinion on Drug Metabolism & Toxicology, 2014
Isoniazid mediates the CYP2B6*6 genotype-dependent interaction between efavirenz and antituberculosis drug therapy through mechanism-based inactivation of CYP2A6.
Court MH et al.
Antimicrobial Agents and Chemotherapy, 2014
Allele and genotype frequencies of CYP2B6 in a Turkish population.
Yuce-Artun N et al.
Molecular Biology Reports, 2014
Deciphering ADME genetic data using an automated haplotype approach.
Guo Y et al.
Pharmacogenetics and Genomics, 2014
CYP2D6 genotype in relation to hot flashes as tamoxifen side effect in a Dutch cohort of the tamoxifen exemestane adjuvant multinational (TEAM) trial.
Dezentjé VO et al.
Breast Cancer Research and Treatment, 2014
Evaluation of influence of single nucleotide polymorphisms in cytochrome P450 2B6 on substrate recognition using computational docking and molecular dynamics simulation.
Kobayashi K et al.
Plos One, 2014
Advances in molecular modeling of human cytochrome P450 polymorphism.
Martiny VY et al.
Journal of Molecular Biology, 2013
The CYP2B6*6 allele significantly alters the N-demethylation of ketamine enantiomers in vitro.
Li Y et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2013
High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Twist GP et al.
Pharmacogenomics, 2013
Influence of CYP2B6 genetic variants on plasma and urine concentrations of bupropion and metabolites at steady state.
Benowitz NL et al.
Pharmacogenetics and Genomics, 2013
Contribution of CYP2B6 alleles in explaining extreme (S)-methadone plasma levels: a CYP2B6 gene resequencing study.
Dobrinas M et al.
Pharmacogenetics and Genomics, 2013
Pharmacogenetics of cytochrome P450 2B6 (CYP2B6): advances on polymorphisms, mechanisms, and clinical relevance.
Zanger UM et al.
Frontiers in Genetics, 2013
Genome-wide association study of plasma efavirenz pharmacokinetics in AIDS Clinical Trials Group protocols implicates several CYP2B6 variants.
Holzinger ER et al.
Pharmacogenetics and Genomics, 2012
Influence of sex on propofol metabolism, a pilot study: implications for propofol anesthesia.
Loryan I et al.
European Journal of Clinical Pharmacology, 2012
Associations between ABCB1, CYP2A6, CYP2B6, CYP2D6, and CYP3A5 alleles in relation to efavirenz and nevirapine pharmacokinetics in HIV-infected individuals.
Heil SG et al.
Therapeutic Drug Monitoring, 2012
Worldwide variation in human drug-metabolism enzyme genes CYP2B6 and UGT2B7: implications for HIV/AIDS treatment.
Li J et al.
Pharmacogenomics, 2012
Which CYP2B6 variants have functional consequences for cyclophosphamide bioactivation?
Helsby NA et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2012