Associated Papers
Natural Products Inhibition of Cytochrome P450 2B6 Activity and Methadone Metabolism.
Wang PF et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2024
Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site.
Angle ED et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2023
Tyrosine Nitration Contributes to Nitric Oxide-Stimulated Degradation of CYP2B6.
Lee CM et al.
Molecular Pharmacology, 2020
Efavirenz Metabolism: Influence of Polymorphic CYP2B6 Variants and Stereochemistry.
Wang PF et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2019
Crystal Structure of CYP2B6 in Complex with an Efavirenz Analog.
Shah MB et al.
International Journal of Molecular Sciences, 2018
Coumarin Derivatives as Substrate Probes of Mammalian Cytochromes P450 2B4 and 2B6: Assessing the Importance of 7-Alkoxy Chain Length, Halogen Substitution, and Non-Active Site Mutations.
Liu J et al.
Biochemistry, 2016
Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes.
Jang HH et al.
Archives of Biochemistry and Biophysics, 2015
Structural and biophysical characterization of human cytochromes P450 2B6 and 2A6 bound to volatile hydrocarbons: analysis and comparison.
Shah MB et al.
Molecular Pharmacology, 2015
The role of cytochrome P450 2B6 and 2B4 substrate access channel residues predicted based on crystal structures of the amlodipine complexes.
Jang HH et al.
Archives of Biochemistry and Biophysics, 2014
Evaluation of influence of single nucleotide polymorphisms in cytochrome P450 2B6 on substrate recognition using computational docking and molecular dynamics simulation.
Kobayashi K et al.
Plos One, 2014
Conformational adaptation of human cytochrome P450 2B6 and rabbit cytochrome P450 2B4 revealed upon binding multiple amlodipine molecules.
Shah MB et al.
Biochemistry, 2012
Effects of the CYP2B6*6 allele on catalytic properties and inhibition of CYP2B6 in vitro: implication for the mechanism of reduced efavirenz metabolism and other CYP2B6 substrates in vivo.
Xu C et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2012
Structures of cytochrome P450 2B6 bound to 4-benzylpyridine and 4-(4-nitrobenzyl)pyridine: insight into inhibitor binding and rearrangement of active site side chains.
Shah MB et al.
Molecular Pharmacology, 2011
Crystal structure of a cytochrome P450 2B6 genetic variant in complex with the inhibitor 4-(4-chlorophenyl)imidazole at 2.0-A resolution.
Gay SC et al.
Molecular Pharmacology, 2010