Associated Papers
Natural Polymorphic Variants in the CYP450 Superfamily: A Review of Potential Structural Mechanisms and Functional Consequences.
Prost R et al.
International Journal of Molecular Sciences, 2025
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y et al.
The Pharmacogenomics Journal, 2024
Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.
Zhang T et al.
Peerj, 2024
Allelic and Genotype Frequencies of CYP2B6∗2 (64C > T) and CYP2B6∗3 (777C > A) in Three Dominant Ethnicities of the Iranian Population.
Khavandegar A et al.
Genetics Research, 2023
Pharmacogenomic profile of actionable molecular variants related to drugs commonly used in anesthesia: WES analysis reveals new mutations.
Parada-Márquez JF et al.
Frontiers in Pharmacology, 2023
Association of Inherited Genetic Factors With Drug-Induced Hepatic Damage Among Children With Acute Lymphoblastic Leukemia.
Yang W et al.
Jama Network Open, 2022
Clinical pharmacogenetic analysis in 5,001 individuals with diagnostic Exome Sequencing data.
Lanillos J et al.
Npj Genomic Medicine, 2022
Pharmacogenetic study of methadone treatment for heroin addiction: associations between drug-metabolizing gene polymorphisms and treatment efficacy.
Chen YJ et al.
Pharmacogenetics and Genomics, 2022
The Efficacy of Cyclophosphamide Combined with Prednisone in Membranous Nephropathy Patients with Different Cytochrome P450 2B6 Gene Polymorphisms and Analysis of Factors Influencing the Efficacy.
Zhang M et al.
Drug Design, Development and Therapy, 2022
Frequency of CYP2B6 Alleles in Major Iranian Ethnicities, Affecting Response to Efavirenz.
Mardi P et al.
Genetics Research, 2022
Comprehensive analysis of important pharmacogenes in Koreans using the DMET™ platform.
Kim B et al.
Translational and Clinical Pharmacology, 2021
Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data.
Neyshaburinezhad N et al.
Journal of Personalized Medicine, 2021
PharmVar GeneFocus: CYP2B6.
Desta Z et al.
Clinical Pharmacology and Therapeutics, 2021
Inter-ethnic genetic variations and novel variant identification in the partial sequences of CYP2B6 gene in Pakistani population.
Ahmed S et al.
Peerj, 2021
The importance of both CYP2C19 and CYP2B6 germline variations in cyclophosphamide pharmacokinetics and clinical outcomes.
Helsby NA et al.
British Journal of Clinical Pharmacology, 2019
Pharmacogenomics in Papua New Guineans: unique profiles and implications for enhancing drug efficacy while improving drug safety.
Tucci JD et al.
Pharmacogenetics and Genomics, 2018
Longrange PCR-based next-generation sequencing in pharmacokinetics and pharmacodynamics study of propofol among patients under general anaesthesia.
Zakerska-Banaszak O et al.
Scientific Reports, 2017
Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.
Zhou Y et al.
Clinical Pharmacology and Therapeutics, 2017
Cytochrome P450 Genetic Variations Can Predict mRNA Expression, Cyclophosphamide 4-Hydroxylation, and Treatment Outcomes in Chinese Patients With Non-Hodgkin's Lymphoma.
Shu W et al.
Journal of Clinical Pharmacology, 2017
Hepatocyte CYP2B6 Can Be Expressed in Cell Culture Systems by Exerting Physiological Levels of Shear: Implications for ADME Testing.
Hammond TG et al.
Journal of Toxicology, 2017
Pharmacokinetics of Bupropion and Its Pharmacologically Active Metabolites in Pregnancy.
Fokina VM et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2016
Polymorphisms and haplotypes of the CYP2B6 detoxification gene in the predisposition of Acute Myeloid Leukemia (AML) and induction of its cytogenetic abnormalities.
Daraki A et al.
Cancer Genetics, 2016
Insights into CYP2B6-mediated drug-drug interactions.
Hedrich WD et al.
Acta Pharmaceutica Sinica. B, 2016
Developmental Expression of CYP2B6: A Comprehensive Analysis of mRNA Expression, Protein Content and Bupropion Hydroxylase Activity and the Impact of Genetic Variation.
Pearce RE et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2016
Influence of CYP2B6 and CYP2C19 polymorphisms on sertraline metabolism in major depression patients.
Yuce-Artun N et al.
International Journal of Clinical Pharmacy, 2016
Role of Pharmacogenetics in Hematopoietic Stem Cell Transplantation Outcome in Children.
Franca R et al.
International Journal of Molecular Sciences, 2015
Allele and genotype frequencies of CYP2B6 in a Turkish population.
Yuce-Artun N et al.
Molecular Biology Reports, 2014
MutPred Splice: machine learning-based prediction of exonic variants that disrupt splicing.
Mort M et al.
Genome Biology, 2014
The G⁵¹⁶T CYP2B6 germline polymorphism affects the risk of acute myeloid leukemia and is associated with specific chromosomal abnormalities.
Daraki A et al.
Plos One, 2014
CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.
Levran O et al.
Addiction Biology, 2013
Frequencies of Cytochrome P450 2B6 and 2C8 Allelic Variants in the Mozambican Population.
Arnaldo P et al.
The Malaysian Journal of Medical Sciences : Mjms, 2013
High-resolution melt analysis to detect sequence variations in highly homologous gene regions: application to CYP2B6.
Twist GP et al.
Pharmacogenomics, 2013
Worldwide variation in human drug-metabolism enzyme genes CYP2B6 and UGT2B7: implications for HIV/AIDS treatment.
Li J et al.
Pharmacogenomics, 2012
Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults.
Uttayamakul S et al.
Aids Research and Therapy, 2010
Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.
Bray J et al.
British Journal of Cancer, 2010
Allele and genotype frequencies of cytochrome P450 2B6 gene in a Mongolian population.
Davaalkham J et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2009
Association of drug metabolism gene polymorphisms with toxicities, graft-versus-host disease and survival after HLA-identical sibling hematopoietic stem cell transplantation for patients with leukemia.
Rocha V et al.
Leukemia, 2009
Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes?
Singh V et al.
Cancer Investigation, 2008
CYP2B6: new insights into a historically overlooked cytochrome P450 isozyme.
Wang H et al.
Current Drug Metabolism, 2008
Aberrant splicing caused by single nucleotide polymorphism c.516G>T [Q172H], a marker of CYP2B6*6, is responsible for decreased expression and activity of CYP2B6 in liver.
Hofmann MH et al.
The Journal of Pharmacology and Experimental Therapeutics, 2008
Gene-gene interactions between CYP2B6 and CYP2A6 in nicotine metabolism.
Ring HZ et al.
Pharmacogenetics and Genomics, 2007
Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26.
Gatanaga H et al.
Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 2007
Pharmacogenetic clinical trial of sustained-release bupropion for smoking cessation.
David SP et al.
Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco, 2007
Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients.
Nakajima M et al.
Pharmacogenetics and Genomics, 2007
Predictive value of known and novel alleles of CYP2B6 for efavirenz plasma concentrations in HIV-infected individuals.
Rotger M et al.
Clinical Pharmacology and Therapeutics, 2007
Toward individualized treatment: prediction of anticancer drug disposition and toxicity with pharmacogenetics.
Deeken JF et al.
Anti-cancer Drugs, 2007
Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese.
Guan S et al.
European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 2006
Intra- and inter-ethnic differences in the allele frequencies of cytochrome P450 2B6 gene in Chinese.
Guan S et al.
Pharmaceutical Research, 2006