Associated Papers
Efavirenz and CYP2C9 Genetic Polymorphisms Reduce CYP2C9 Activity in Healthy Participants.
Kim JD et al.
Clinical and Translational Science, 2026
Pharmacogenetic influence on bupropion bioactivation and clinical outcomes in major depressive disorder.
Kharasch ED et al.
The Journal of Pharmacology and Experimental Therapeutics, 2026
Whole exome sequencing analysis of suicidal thoughts and behaviors in a veteran cohort implicates inflammatory pathways and genes previously associated with psychiatric and neurodegenerative diseases.
Garrett ME et al.
Journal of Affective Disorders, 2026
GenoStaR: An R Package for Genotype to Star Allele Conversion for Major Cytochrome P450 Family of Genes.
Coulter AJ et al.
Clinical Pharmacology and Therapeutics, 2026
Clinical Implementation of Pharmacogenomics and Drug-Drug Interaction Screening in a German Academic Teaching Hospital and Outpatient Follow-Up.
Tremmel R et al.
Clinical Pharmacology and Therapeutics, 2026
Genetic landscape and therapeutic evolution of cyclophosphamide: spotlight on breast cancer.
Cao J et al.
Journal of Chemotherapy (florence, Italy), 2025
Development and Verification of Virtual Population Models for Predicting Drug Pharmacokinetics in Ethnic North American Populations.
Ezuruike U et al.
Cpt: Pharmacometrics & Systems Pharmacology, 2025
Opportunities and Challenges of Population Pharmacogenomics.
Zhou Y et al.
Annals of Human Genetics, 2025
Influence of pharmacokinetics-related gene polymorphisms on plasma levels of clozapine and its metabolites in Japanese patients with schizophrenia.
Kinoshita S et al.
Pcn Reports : Psychiatry and Clinical Neurosciences, 2025
Impact of genetic variations on the pharmacokinetics, dose requirements, and clinical effects of propofol: a systematic review.
Gerstman MD et al.
British Journal of Anaesthesia, 2025
Natural Polymorphic Variants in the CYP450 Superfamily: A Review of Potential Structural Mechanisms and Functional Consequences.
Prost R et al.
International Journal of Molecular Sciences, 2025
Molecular Determinants of the Human Retinal Pigment Epithelium Cell Fate and Potential Pharmacogenomic Targets for Precision Medicine.
Zibetti C
International Journal of Molecular Sciences, 2025
Association of CYP2B6 and OPRM1 Genotypes with Methadone Dose Requirements and Serum Concentrations in a Vietnamese Cohorts.
Nguyen QG et al.
Balkan Journal of Medical Genetics : Bjmg, 2025
Contrastive sequence signatures between the both sides of a recombination spot reveal an adaptation at PPARD locus from standing variation for pleiotropy since out-of-Africa dispersal.
Shou W et al.
Bmc Genomics, 2025
Relationships among CYP2B6 genetic variants and serum levels of multiple polychlorinated biphenyls and hydroxylated metabolites in a Japanese population.
Lyu Z et al.
Journal of Hazardous Materials, 2025
Gene polymorphisms associated with immunosuppressant adverse effects in systemic lupus erythematosus: a narrative review.
Hamdani S et al.
Frontiers in Genetics, 2025
StarPhase: Comprehensive Phase-Aware Pharmacogenomic Diplotyper for Long-Read Sequencing Data.
Holt JM et al.
Biorxiv : the Preprint Server for Biology, 2024
Clinical Benefits and Utility of Pretherapeutic DPYD and UGT1A1 Testing in Gastrointestinal Cancer: A Secondary Analysis of the PREPARE Randomized Clinical Trial.
Roncato R et al.
Jama Network Open, 2024
Methadone metabolism and cytochrome P450 polymorphisms: a systematic review and meta-analysis.
Eum S et al.
Expert Opinion on Drug Metabolism & Toxicology, 2024
Association between the CYP2B6 polymorphisms and nonnucleoside reverse transcriptase inhibitors drug-induced liver injury: a systematic review and meta-analysis.
Chanhom N et al.
Scientific Reports, 2024
Clinical Pharmacogenetics Implementation Consortium Guideline for CYP2B6 Genotype and Methadone Therapy.
Robinson KM et al.
Clinical Pharmacology and Therapeutics, 2024
Frequency of pharmacogenomic variation and medication exposures among All of Us Participants.
Haddad A et al.
Medrxiv : the Preprint Server for Health Sciences, 2024
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y et al.
The Pharmacogenomics Journal, 2024
Uncoupling of Cytochrome P450 2B6 and stimulation of reactive oxygen species production in pharmacogenomic alleles affected by interethnic variability.
Yamoune S et al.
Biochimica Et Biophysica Acta. General Subjects, 2024
Pharmacogenetic Influence on Stereoselective Steady-State Disposition of Bupropion.
Kharasch ED et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2024
Genetic variants, haplotype determination, and function of novel alleles of CYP2B6 in a Han Chinese population.
Zhang LQ et al.
Heliyon, 2024
Characterization of CYP2B6 and CYP2A6 Pharmacogenetic Variation in Sub-Saharan African Populations.
Twesigomwe D et al.
Clinical Pharmacology and Therapeutics, 2024
Natural Products Inhibition of Cytochrome P450 2B6 Activity and Methadone Metabolism.
Wang PF et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2024
The role of polymorphic cytochrome P450 gene (CYP2B6) in B-chronic lymphocytic leukemia (B-CLL) incidence and outcome among Egyptian patients.
Al-Adl M et al.
Oncology Research, 2024
GTExome: Modeling commonly expressed missense mutations in the human genome.
Hoffman J et al.
Plos One, 2024
Cyclophosphamide Pharmacogenomic Variation in Cancer Treatment and Its Effect on Bioactivation and Pharmacokinetics.
El-Serafi I et al.
Advances in Pharmacological and Pharmaceutical Sciences, 2024
The Influence of CYP2B6 Variants and Administration of Propofol on Patient Outcomes after Traumatic Brain Injury.
O'Meara K et al.
Neurotrauma Reports, 2024
Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.
Zhang T et al.
Peerj, 2024
Genetic polymorphisms of CYP2B6 is a risk of metabolic associated fatty liver disease in Chinese population.
Zhang J et al.
Toxicology and Applied Pharmacology, 2023
GTExome: Modeling commonly expressed missense mutations in the human genome.
Hoffman J et al.
Biorxiv : the Preprint Server for Biology, 2023
G-quadruplex forming sequences in the genes coding for cytochrome P450 enzymes and their potential roles in drug metabolism.
Saad M et al.
Biochimie, 2023
Neonatal opioid toxicity: opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression.
Baldo BA
Archives of Toxicology, 2023
Association between CYP2B6 genetic variability and cyclophosphamide therapy in pediatric patients with neuroblastoma.
Mangó K et al.
Scientific Reports, 2023
Pharmacogenomic variation in the Malagasy population: implications for the antimalarial drug primaquine metabolism.
Cramer EY et al.
Pharmacogenomics, 2023
Genetic and non-genetic factors influencing efavirenz population pharmacokinetics among human immunodeficiency virus-1-infected children in Ethiopia.
Chala A et al.
Cpt: Pharmacometrics & Systems Pharmacology, 2023
Mechanistic Modeling of the Drug-Drug Interaction Between Efavirenz and Dolutegravir: Is This Interaction Clinically Relevant When Switching From Efavirenz to Dolutegravir During Pregnancy?
Dallmann A et al.
Journal of Clinical Pharmacology, 2023
Pharmacogenetics of Lethal Opioid Overdose: Review of Current Evidence and Preliminary Results from a Pilot Study.
Magarbeh L et al.
Journal of Personalized Medicine, 2023
Multidisciplinary Insights into the Structure-Function Relationship of the CYP2B6 Active Site.
Angle ED et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2023
Human Cytochrome P450 1, 2, 3 Families as Pharmacogenes with Emphases on Their Antimalarial and Antituberculosis Drugs and Prevalent African Alleles.
Chamboko CR et al.
International Journal of Molecular Sciences, 2023
Effects of rifampicin, CYP2B6 and ABCB1 polymorphisms on efavirenz plasma concentration in Chinese patients living with HIV and tuberculosis.
Zhang L et al.
International Journal of Std & Aids, 2023
Allelic and Genotype Frequencies of CYP2B6∗2 (64C > T) and CYP2B6∗3 (777C > A) in Three Dominant Ethnicities of the Iranian Population.
Khavandegar A et al.
Genetics Research, 2023
Development of Novel Mass Spectrum-Based Assay for Simultaneous Detection of 36 Variants in the 14 Pharmacogenetic Genes for the Japanese Population.
Yamamoto N et al.
Biological & Pharmaceutical Bulletin, 2023
Influence of CYP450 Enzymes and ABCB1 Polymorphisms on Clopidogrel Response in Moroccan Patients with Acute Coronary Syndromes.
Mouhrach I et al.
Pharmacogenomics and Personalized Medicine, 2023