Varaico: Literature-Extracted Genetic Variants

Gene:CYP2B6
Variant:p.M459V
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CYP2B6

NM_000767.5:p.M459V

Associated Papers

APF2: an improved ensemble method for pharmacogenomic variant effect prediction.

Zhou Y et al.

The Pharmacogenomics Journal, 2024

38802404 (PubMed )
Supplement: 41397_2024_338_MOESM2_ESM.xlsx › Sheet1

Genetic variants, haplotype determination, and function of novel alleles of CYP2B6 in a Han Chinese population.

Zhang LQ et al.

Heliyon, 2024

Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data.

Neyshaburinezhad N et al.

Journal of Personalized Medicine, 2021

34442448 (PubMed )
Supplement: jpm-11-00804-s001.zip › jpm-1270394-supplementary.pdf

Autoinflammatory Keratinization Disease With Hepatitis and Autism Reveals Roles for JAK1 Kinase Hyperactivity in Autoinflammation.

Takeichi T et al.

Frontiers in Immunology, 2021

35046931 (PubMed )
Supplement: DataSheet_1.pdf

An optimized prediction framework to assess the functional impact of pharmacogenetic variants.

Zhou Y et al.

The Pharmacogenomics Journal, 2019

30206299 (PubMed )
Supplement: 41397_2018_44_MOESM5_ESM.xlsx › Sheet1

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects.

Zhou Y et al.

Clinical Pharmacology and Therapeutics, 2017

The use of pharmacogenetics in clinical practice for the treatment of individuals with HIV infection in Thailand.

Bushyakanist A et al.

Pharmacogenomics and Personalized Medicine, 2015

A pharmacogenomic prospective randomized controlled trial of CYP2B6 polymorphisms and efavirenz dose adjustment among HIV-infected Thai patients: a pilot study.

Damronglerd P et al.

Pharmacogenomics and Personalized Medicine, 2015

Low level of efavirenz in HIV-1-infected Thai adults is associated with the CYP2B6 polymorphism.

Sukasem C et al.

Infection, 2014

CYP2B6 haplotype and biological factors responsible for hepatotoxicity in HIV-infected patients receiving efavirenz-based antiretroviral therapy.

Manosuthi W et al.

International Journal of Antimicrobial Agents, 2014

CYP2B6 18492T->C polymorphism compromises efavirenz concentration in coinfected HIV and tuberculosis patients carrying CYP2B6 haplotype *1/*1.

Manosuthi W et al.

Antimicrobial Agents and Chemotherapy, 2014

Multi-ethnic cytochrome-P450 copy number profiling: novel pharmacogenetic alleles and mechanism of copy number variation formation.

Martis S et al.

The Pharmacogenomics Journal, 2013

Impact of pharmacogenetic markers of CYP2B6, clinical factors, and drug-drug interaction on efavirenz concentrations in HIV/tuberculosis-coinfected patients.

Manosuthi W et al.

Antimicrobial Agents and Chemotherapy, 2013

High plasma efavirenz concentration and CYP2B6 polymorphisms in Thai HIV-1 infections.

Sukasem C et al.

Drug Metabolism and Pharmacokinetics, 2013

Pharmacogenetic markers of CYP2B6 associated with efavirenz plasma concentrations in HIV-1 infected Thai adults.

Sukasem C et al.

British Journal of Clinical Pharmacology, 2012

A novel polymorphism in ABCB1 gene, CYP2B6*6 and sex predict single-dose efavirenz population pharmacokinetics in Ugandans.

Mukonzo JK et al.

British Journal of Clinical Pharmacology, 2009

Allele and genotype frequencies of cytochrome P450 2B6 gene in a Mongolian population.

Davaalkham J et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2009

Successful efavirenz dose reduction in HIV type 1-infected individuals with cytochrome P450 2B6 *6 and *26.

Gatanaga H et al.

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America, 2007

The relationship between the pharmacology of antiepileptic drugs and human gene variation: an overview.

Ferraro TN et al.

Epilepsy & Behavior : E&b, 2005

Three novel single nucleotide polymorphisms (SNPs) of the CYP2B6 gene in Japanese individuals.

Hiratsuka M et al.

Drug Metabolism and Pharmacokinetics, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."