Associated Papers
Genetic variants of cytochrome P450 2C21 identified by screening 6344 dogs influenced oxidations of the probe drug omeprazole.
Uno Y et al.
Biochemical Pharmacology, 2025
Natural Polymorphic Variants in the CYP450 Superfamily: A Review of Potential Structural Mechanisms and Functional Consequences.
Prost R et al.
International Journal of Molecular Sciences, 2025
In vitro assessment of the impact of 30 CYP2C19 variants on citalopram metabolism.
Wang P et al.
Peerj, 2025
APF2: an improved ensemble method for pharmacogenomic variant effect prediction.
Zhou Y et al.
The Pharmacogenomics Journal, 2024
Functional evaluation of CYP2C19 and CYP3A4 gene polymorphism on ibuprofen metabolism.
Yuan LJ et al.
Toxicology and Applied Pharmacology, 2023
Effects of 31 recombinant CYP2C19 variants on clomipramine metabolism in vitro.
Lan T et al.
Journal of Psychopharmacology (oxford, England), 2021
An optimized prediction framework to assess the functional impact of pharmacogenetic variants.
Zhou Y et al.
The Pharmacogenomics Journal, 2019
Functional characterization of CYP2C19 variants in nebivolol 4-hydroxlation in vitro.
Zhou XY et al.
Drug Testing and Analysis, 2018
Pharmacogenomic Impact of CYP2C19 Variation on Clopidogrel Therapy in Precision Cardiovascular Medicine.
Brown SA et al.
Journal of Personalized Medicine, 2018
The effects of cytochrome P450 2C19 polymorphism on the metabolism of voriconazole in vitro.
Xu RA et al.
Infection and Drug Resistance, 2018
Effects of CYP2C19 variants on methadone metabolism in vitro.
Lan T et al.
Drug Testing and Analysis, 2017
Effects of CYP2C19 Variants on Fluoxetine Metabolism in vitro.
Fang P et al.
Pharmacology, 2017
Genetic Polymorphisms and in Vitro Functional Characterization of CYP2C8, CYP2C9, and CYP2C19 Allelic Variants.
Hiratsuka M
Biological & Pharmaceutical Bulletin, 2016
Functional characterization of 21 CYP2C19 allelic variants for clopidogrel 2-oxidation.
Takahashi M et al.
The Pharmacogenomics Journal, 2015
Molecular mechanisms of genetic variation and transcriptional regulation of CYP2C19.
Helsby NA et al.
Frontiers in Genetics, 2012
Evaluation of the effects of 18 non-synonymous single-nucleotide polymorphisms of CYP450 2C19 on in vitro drug inhibition potential by a fluorescence-based high-throughput assay.
Wang H et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2011
Evaluation of the effects of 20 nonsynonymous single nucleotide polymorphisms of CYP2C19 on S-mephenytoin 4'-hydroxylation and omeprazole 5'-hydroxylation.
Wang H et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2011
Functional characterization of two novel CYP2C19 variants (CYP2C19*18 and CYP2C19*19) found in a Japanese population.
Hanioka N et al.
Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2007
Genetic variations and haplotypes of CYP2C19 in a Japanese population.
Fukushima-Uesaka H et al.
Drug Metabolism and Pharmacokinetics, 2005