Varaico: Literature-Extracted Genetic Variants

Gene:CYP2C8
Variant:p.R144C
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CYP2C8

NM_000770.3:p.R144C

Associated Papers

The Role of Pharmacogenetic Biomarkers in Pain.

Martin da Silva I et al.

Biomedicines, 2025

Mathematical modeling of pharmacokinetics and pharmacodynamics of losartan in relation to CYP2C9 allele variants.

Babaev D et al.

Frontiers in Systems Biology, 2025

Gene Polymorphism of Biotransformation Enzymes and Ciprofloxacin Pharmacokinetics in Pediatric Patients with Cystic Fibrosis.

Zyryanov SK et al.

Biomedicines, 2022

Ethnic Diversity and Warfarin Pharmacogenomics.

Asiimwe IG et al.

Frontiers in Pharmacology, 2022

35444556 (PubMed )
Supplement: Table1.DOCX

Insights into the Genetic Variations of Human Cytochrome P450 2C9: Structural Analysis, Characterization and Comparison.

Parikh SJ et al.

International Journal of Molecular Sciences, 2021

Role of Genetic Variations in the Hepatic Handling of Drugs.

Marin JJG et al.

International Journal of Molecular Sciences, 2020

Assessment of pharmacogenomic SLCO1B1 assay for prediction of neuromuscular pain in type 2 diabetes mellitus and cardiovascular patients: preliminary results.

Licito A et al.

European Review for Medical and Pharmacological Sciences, 2020

Pharmacogenomics of CYP2C9: Functional and Clinical Considerations.

Daly AK et al.

Journal of Personalized Medicine, 2017

Distribution of CYP2C8 and CYP2C9 amino acid substitution alleles in South Indian diabetes patients: A genotypic and computational protein phenotype study.

Rao DK et al.

Clinical and Experimental Pharmacology & Physiology, 2017

Pharmacogenomics of the cytochrome P450 2C family: impacts of amino acid variations on drug metabolism.

Isvoran A et al.

Drug Discovery Today, 2017

Role of Cytochrome P450 2C8 in Drug Metabolism and Interactions.

Backman JT et al.

Pharmacological Reviews, 2016

[POLYMORPHISM OF CYP2C9 GENE AND RISK OF HEPATOTOXICITY DEVELOPMENT DURING ANTIRETROVIRAL THERAPY.]

Kurbat MN et al.

Eksperimental'naia I Klinicheskaia Farmakologiia, 2016

Characterization of drug-metabolizing enzymes CYP2C9, CYP2C19 polymorphisms in Tunisian, Kuwaiti and Bahraini populations.

Abdelhedi R et al.

Journal of Genetics, 2015

Genetic polymorphisms of ALOX5AP and CYP3A5 increase susceptibility to ischemic stroke and are associated with atherothrombotic events in stroke patients.

Yi X et al.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association, 2015

Genetic markers in the EET metabolic pathway are associated with outcomes in patients with aneurysmal subarachnoid hemorrhage.

Donnelly MK et al.

Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism, 2015

Pharmacogenetics in Jewish populations.

Yang Y et al.

Drug Metabolism and Drug Interactions, 2014

Polymorphic metabolism by functional alterations of human cytochrome P450 enzymes.

Lee IS et al.

Archives of Pharmacal Research, 2011

Polymorphisms of human cytochrome P450 2C9 and the functional relevance.

Zhou SF et al.

Toxicology, 2010

CYP2C9*3 Loss-of-Function Allele Is Associated With Acute Upper Gastrointestinal Bleeding Related to the Use of NSAIDs Other Than Aspirin.

Carbonell N et al.

Clinical Pharmacology and Therapeutics, 2010

Pharmacogenetics in diabetes.

Pearson ER

Current Diabetes Reports, 2009

Pharmacogenetic testing of CYP2C9 and VKORC1 alleles for warfarin.

Flockhart DA et al.

Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2008

Contribution of CYP2C9 to variability in vitamin K antagonist metabolism.

Daly AK et al.

Expert Opinion on Drug Metabolism & Toxicology, 2006

Predicting drug response and toxicity based on gene polymorphisms.

Robert J et al.

Critical Reviews in Oncology/hematology, 2005

Clinical consequences of cytochrome P450 2C9 polymorphisms.

Kirchheiner J et al.

Clinical Pharmacology and Therapeutics, 2005

Pyrosequencing method for genotyping cytochrome P450 CYP2C8 and CYP2C9 enzymes.

Hruska MW et al.

Clinical Chemistry, 2004

Novel CYP2C9 genetic variants in Asian subjects and their influence on maintenance warfarin dose.

Zhao F et al.

Clinical Pharmacology and Therapeutics, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."