Associated Papers
Cytochrome P450 1A1, 2C9, 2C19, and 3A4 Polymorphisms Account for Interindividual Variability of Toxicological Drug Metabolism in Cynomolgus Macaques.
Uno Y et al.
Chemical Research in Toxicology, 2018
Genetic polymorphisms of drug-metabolizing cytochrome P450 enzymes in cynomolgus and rhesus monkeys and common marmosets in preclinical studies for humans.
Uno Y et al.
Biochemical Pharmacology, 2018
Development of genotyping method for functionally relevant variants of cytochromes P450 in cynomolgus macaques.
Uno Y et al.
Journal of Veterinary Pharmacology and Therapeutics, 2018
Efavirenz clearances in vitro and in vivo in six cynomolgus monkeys associated with polymorphic cytochrome P450 2C9 and simulated by individual physiologically based pharmacokinetic models.
Utoh M et al.
Biopharmaceutics & Drug Disposition, 2017
Corrigendum to "Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9" [Drug Metab Pharmacokinet 30 (2015) 130-132].
Uno Y et al.
Drug Metabolism and Pharmacokinetics, 2017
In vivo individual variations in pharmacokinetics of efavirenz in cynomolgus monkeys genotyped for cytochrome P450 2C9.
Iwasaki K et al.
Biopharmaceutics & Drug Disposition, 2016
Genetic polymorphism of cynomolgus and rhesus macaque CYP2C9.
Uno Y et al.
Drug Metabolism and Pharmacokinetics, 2015
CYP2C19 polymorphisms account for inter-individual variability of drug metabolism in cynomolgus macaques.
Uno Y et al.
Biochemical Pharmacology, 2014
Polymorphisms of human cytochrome P450 2C9 and the functional relevance.
Zhou SF et al.
Toxicology, 2010
Genetically based impairment in CYP2C8- and CYP2C9-dependent NSAID metabolism as a risk factor for gastrointestinal bleeding: is a combination of pharmacogenomics and metabolomics required to improve personalized medicine?
Agúndez JA et al.
Expert Opinion on Drug Metabolism & Toxicology, 2009
A bioinformatics approach for the phenotype prediction of nonsynonymous single nucleotide polymorphisms in human cytochromes P450.
Wang LL et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2009
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