Associated Papers
Mining of molecular insights of CYP2A6 and its variants complex with coumarin (CYP2A6*-coumarin) using molecular dynamics simulation.
Yadav A et al.
Journal of Biomolecular Structure & Dynamics, 2023
Heterologous Expression and Functional Characterization of Novel CYP2C9 Variants Identified in the Alaska Native People.
McDonald MG et al.
The Journal of Pharmacology and Experimental Therapeutics, 2020
Distal effect of amino acid substitutions in CYP2C9 polymorphic variants causes differences in interatomic interactions against (S)-warfarin.
Lertkiatmongkol P et al.
Plos One, 2013
In vitro assessment of the allelic variants of cytochrome P450.
Hiratsuka M
Drug Metabolism and Pharmacokinetics, 2012
The blood-brain barrier thyroxine transporter organic anion-transporting polypeptide 1c1 displays atypical transport kinetics.
Westholm DE et al.
Endocrinology, 2009
CYP2C9 amino acid residues influencing phenytoin turnover and metabolite regio- and stereochemistry.
Mosher CM et al.
The Journal of Pharmacology and Experimental Therapeutics, 2009
Prediction of the effects of genetic polymorphism on the pharmacokinetics of CYP2C9 substrates from in vitro data.
Kusama M et al.
Pharmaceutical Research, 2009
Functional analysis of phenylalanine residues in the active site of cytochrome P450 2C9.
Mosher CM et al.
Biochemistry, 2008
Differential contribution of active site residues in substrate recognition sites 1 and 5 to cytochrome P450 2C8 substrate selectivity and regioselectivity.
Kerdpin O et al.
Biochemistry, 2004
Generation and evaluation of a CYP2C9 heteroactivation pharmacophore.
Egnell AC et al.
The Journal of Pharmacology and Experimental Therapeutics, 2003
Polymorphic variants (CYP2C9*3 and CYP2C9*5) and the F114L active site mutation of CYP2C9: effect on atypical kinetic metabolism profiles.
Tracy TS et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2002
Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.
Haining RL et al.
Biochemistry, 1999
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