Associated Papers
EnzyACT: A Novel Deep Learning Method to Predict the Impacts of Single and Multiple Mutations on Enzyme Activity.
Li G et al.
Journal of Chemical Information and Modeling, 2024
Insights into molecular mechanisms of drug metabolism dysfunction of human CYP2C9*30.
Louet M et al.
Plos One, 2018
Distal effect of amino acid substitutions in CYP2C9 polymorphic variants causes differences in interatomic interactions against (S)-warfarin.
Lertkiatmongkol P et al.
Plos One, 2013
Mechanism of the decrease in catalytic activity of human cytochrome P450 2C9 polymorphic variants investigated by computational analysis.
Sano E et al.
Journal of Computational Chemistry, 2010
Important amino acid residues that confer CYP2C19 selective activity to CYP2C9.
Wada Y et al.
Journal of Biochemistry, 2008
Multiple molecular dynamics simulations of human p450 monooxygenase CYP2C9: the molecular basis of substrate binding and regioselectivity toward warfarin.
Seifert A et al.
Proteins, 2006
The structure of human cytochrome P450 2C9 complexed with flurbiprofen at 2.0-A resolution.
Wester MR et al.
The Journal of Biological Chemistry, 2004
Identification of human CYP2C19 residues that confer S-mephenytoin 4'-hydroxylation activity to CYP2C9.
Tsao CC et al.
Biochemistry, 2001
Identification of residues 99, 220, and 221 of human cytochrome P450 2C19 as key determinants of omeprazole activity.
Ibeanu GC et al.
The Journal of Biological Chemistry, 1996
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