Associated Papers
Microsecond MD simulations of human CYP2D6 wild-type and five allelic variants reveal mechanistic insights on the function.
Don CG et al.
Plos One, 2018
Double site saturation mutagenesis of the human cytochrome P450 2D6 results in regioselective steroid hydroxylation.
Geier M et al.
The Febs Journal, 2013
Active site substitution A82W improves the regioselectivity of steroid hydroxylation by cytochrome P450 BM3 mutants as rationalized by spin relaxation nuclear magnetic resonance studies.
Rea V et al.
Biochemistry, 2012
New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.
Wang B et al.
Drug Metabolism Reviews, 2009
Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.
Maréchal JD et al.
British Journal of Pharmacology, 2008
The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent.
Lussenburg BM et al.
Biochemical Pharmacology, 2005
Progress in cytochrome P450 active site modeling.
Kemp CA et al.
Archives of Biochemistry and Biophysics, 2005
Essential requirements for substrate binding affinity and selectivity toward human CYP2 family enzymes.
Lewis DF
Archives of Biochemistry and Biophysics, 2003
Determinants of the substrate specificity of human cytochrome P-450 CYP2D6: design and construction of a mutant with testosterone hydroxylase activity.
Smith G et al.
The Biochemical Journal, 1998
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