Associated Papers
Microsecond MD simulations of human CYP2D6 wild-type and five allelic variants reveal mechanistic insights on the function.
Don CG et al.
Plos One, 2018
New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.
Wang B et al.
Drug Metabolism Reviews, 2009
Re-engineering of CYP2C9 to probe acid-base substrate selectivity.
Tai G et al.
Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2008
Insights into drug metabolism by cytochromes P450 from modelling studies of CYP2D6-drug interactions.
Maréchal JD et al.
British Journal of Pharmacology, 2008
Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.
McLaughlin LA et al.
The Journal of Biological Chemistry, 2005
Progress in cytochrome P450 active site modeling.
Kemp CA et al.
Archives of Biochemistry and Biophysics, 2005
Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.
Guengerich FP et al.
Biochemistry, 2003
Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.
Paine MJ et al.
The Journal of Biological Chemistry, 2003
Select a paper to view details