Varaico: Literature-Extracted Genetic Variants

Gene:CYP2D6
Variant:p.E216K
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CYP2D6

NM_000106.6:p.E216K

Associated Papers

Polymorphisms of tumor necrosis factor-α promoter region for susceptibility to HLA-B27-positive ankylosing spondylitis in Korean population.

Chung WT et al.

Rheumatology International, 2011

New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme.

Wang B et al.

Drug Metabolism Reviews, 2009

Why is quinidine an inhibitor of cytochrome P450 2D6? The role of key active-site residues in quinidine binding.

McLaughlin LA et al.

The Journal of Biological Chemistry, 2005

Role of glutamic acid 216 in cytochrome P450 2D6 substrate binding and catalysis.

Guengerich FP et al.

Biochemistry, 2003

Residues glutamate 216 and aspartate 301 are key determinants of substrate specificity and product regioselectivity in cytochrome P450 2D6.

Paine MJ et al.

The Journal of Biological Chemistry, 2003

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."