Varaico: Literature-Extracted Genetic Variants

Gene:CYP2D6
Variant:p.P55T
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CYP2D6

NM_000106.6:p.P55T

Associated Papers

Pharmacogenetic pilot study of CYP2D6 and CYP1A2 genes in Italian patients with non-dystrophic myotonia and myotonic dystrophy treated with mexiletine.

Brugnoni R et al.

Gene, 2025

Pharmacogenetics of Praziquantel Metabolism: Evaluating the Cytochrome P450 Genes of Zimbabwean Patients During a Schistosomiasis Treatment.

Zdesenko G et al.

Frontiers in Genetics, 2022

35754834 (PubMed )
Supplement: DataSheet1.pdf

How Can Drug Metabolism and Transporter Genetics Inform Psychotropic Prescribing?

Carvalho Henriques B et al.

Frontiers in Genetics, 2020

African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug Development.

Rajman I et al.

Ebiomedicine, 2017

28237373 (PubMed )
Supplement: mmc1.xlsx › References

Gene polymorphisms and contents of cytochrome P450s have only limited effects on metabolic activities in human liver microsomes.

Gao N et al.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 2016

Characterization of 137 Genomic DNA Reference Materials for 28 Pharmacogenetic Genes: A GeT-RM Collaborative Project.

Pratt VM et al.

The Journal of Molecular Diagnostics : Jmd, 2016

Structure, function, regulation and polymorphism and the clinical significance of human cytochrome P450 1A2.

Zhou SF et al.

Drug Metabolism Reviews, 2010

Carriers of the UGT1A4 142T>G gene variant are predisposed to reduced olanzapine exposure--an impact similar to male gender or smoking in schizophrenic patients.

Ghotbi R et al.

European Journal of Clinical Pharmacology, 2010

Insights into the substrate specificity, inhibitors, regulation, and polymorphisms and the clinical impact of human cytochrome P450 1A2.

Zhou SF et al.

The Aaps Journal, 2009

CYP1A2 genetic polymorphisms and adenocarcinoma lung cancer risk in the Tunisian population.

B'chir F et al.

Life Sciences, 2009

Functional pharmacogenetics/genomics of human cytochromes P450 involved in drug biotransformation.

Zanger UM et al.

Analytical and Bioanalytical Chemistry, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."