Varaico: Literature-Extracted Genetic Variants

Gene:CYP2D6
Variant:p.R25W
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CYP2D6

NM_000106.6:p.R25W

Associated Papers

The genetic landscape of major drug metabolizing cytochrome P450 genes-an updated analysis of population-scale sequencing data.

Zhou Y et al.

The Pharmacogenomics Journal, 2022

36068297 (PubMed )
Supplement: 41397_2022_288_MOESM4_ESM.xlsx › Sheet1

Development and Analytical Validation of a 29 Gene Clinical Pharmacogenetic Genotyping Panel: Multi-Ethnic Allele and Copy Number Variant Detection.

Scott SA et al.

Clinical and Translational Science, 2021

32931151 (PubMed )
Supplement: CTS-14-204-s001.xlsx › Table_S1

Assessing the capability of massively parallel sequencing for opportunistic pharmacogenetic screening.

Ng D et al.

Genetics in Medicine : Official Journal of the American College of Medical Genetics, 2017

27537706 (PubMed )
Supplement: NIHMS802548-supplement-Table_S4.pdf

Sequencing CYP2D6 for the detection of poor-metabolizers in post-mortem blood samples with tramadol.

Fonseca S et al.

Forensic Science International, 2016

Effects of 22 Novel CYP2D6 Variants Found in the Chinese Population on the Bufuralol and Dextromethorphan Metabolisms In Vitro.

Cai J et al.

Basic & Clinical Pharmacology & Toxicology, 2016

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro.

Wang Z et al.

Drug Design, Development and Therapy, 2016

Advances in molecular modeling of human cytochrome P450 polymorphism.

Martiny VY et al.

Journal of Molecular Biology, 2013

Complexities of CYP2D6 gene analysis and interpretation.

Gaedigk A

International Review of Psychiatry (abingdon, England), 2013

Polymorphism of human cytochrome P450 2D6 and its clinical significance: Part I.

Zhou SF

Clinical Pharmacokinetics, 2009

Functional characterization of 17 CYP2D6 allelic variants (CYP2D6.2, 10, 14A-B, 18, 27, 36, 39, 47-51, 53-55, and 57).

Sakuyama K et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2008

Novel nonsynonymous single nucleotide polymorphisms in the CYP2D6 gene.

Soyama A et al.

Drug Metabolism and Pharmacokinetics, 2004

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."