Varaico: Literature-Extracted Genetic Variants

Gene:CYP2E1
Variant:p.V389I
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CYP2E1

NM_000773.4:p.V389I

Associated Papers

Comprehensive functional characterization of rare and known CYP2E1 allelic variants identified in a Japanese population.

Ohmori Y et al.

Biochemical Pharmacology, 2025

Natural Polymorphic Variants in the CYP450 Superfamily: A Review of Potential Structural Mechanisms and Functional Consequences.

Prost R et al.

International Journal of Molecular Sciences, 2025

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Frequency of Important CYP450 Enzyme Gene Polymorphisms in the Iranian Population in Comparison with Other Major Populations: A Comprehensive Review of the Human Data.

Neyshaburinezhad N et al.

Journal of Personalized Medicine, 2021

34442448 (PubMed )
Supplement: jpm-11-00804-s001.zip › jpm-1270394-supplementary.pdf

Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese.

Wang T et al.

Peerj, 2020

PRIMA-1MET-induced neuroblastoma cell death is modulated by p53 and mycn through glutathione level.

Mlakar V et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2019

30755224 (PubMed )
Supplement: 13046_2019_1066_MOESM1_ESM.xlsx › LAN6

Polymorphisms of drug-metabolizing enzyme CYP2E1 in Chinese Uygur population.

Zhu L et al.

Medicine, 2018

Human cytochrome P450 2E1 mutations that alter mitochondrial targeting efficiency and susceptibility to ethanol-induced toxicity in cellular models.

Bansal S et al.

The Journal of Biological Chemistry, 2013

Phenotype prediction of deleterious nonsynonymous single nucleotide polymorphisms in human alcohol metabolism-related genes: a bioinformatics study.

Wang LL et al.

Alcohol (fayetteville, N.y.), 2010

Functional characterization of human cytochrome P4502E1 allelic variants: in vitro metabolism of benzene and toluene by recombinant enzymes expressed in yeast cells.

Hanioka N et al.

Archives of Toxicology, 2010

Genetic polymorphism in CYP2E1: Population distribution of CYP2E1 activity.

Neafsey P et al.

Journal of Toxicology and Environmental Health. Part B, Critical Reviews, 2009

[Cancer pharmacogenetics: study of genetically determined variations on cancer susceptibility due to xenobiotic exposure].

Quiñones L et al.

Revista Medica De Chile, 2006

The human genome project and novel aspects of cytochrome P450 research.

Ingelman-Sundberg M

Toxicology and Applied Pharmacology, 2005

Human drug metabolising cytochrome P450 enzymes: properties and polymorphisms.

Ingelman-Sundberg M

Naunyn-schmiedeberg's Archives of Pharmacology, 2004

Functional characterization of three human cytochrome p450 2E1 variants with amino acid substitutions.

Hanioka N et al.

Xenobiotica; the Fate of Foreign Compounds in Biological Systems, 2003

The cytochrome P-450 isoenzyme CYP2E1 in the biological processing of industrial chemicals: consequences for occupational and environmental medicine.

Bolt HM et al.

International Archives of Occupational and Environmental Health, 2003

Metabolic and ethnic determinants of alcohol drinking habits and vulnerability to alcohol-related disorder.

Harada S et al.

Alcoholism, Clinical and Experimental Research, 2001

Mutations in the exons and exon-intron junction regions of human cytochrome P-4502E1 gene and alcoholism.

Itoga S et al.

Alcoholism, Clinical and Experimental Research, 1999

[Genetic polymorphism of human CYP2E1: new allels detected in exons and exon-intron junctions].

Itoga S et al.

Nihon Arukoru Yakubutsu Igakkai Zasshi = Japanese Journal of Alcohol Studies & Drug Dependence, 1998

Genetic polymorphism of human CYP2E1: characterization of two variant alleles.

Hu Y et al.

Molecular Pharmacology, 1997

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."