Varaico: Literature-Extracted Genetic Variants

Gene:CYP3A4
Variant:p.L172F
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CYP3A4

NM_017460.6:p.L172F

Associated Papers

Association of CYP2B6 and OPRM1 Genotypes with Methadone Dose Requirements and Serum Concentrations in a Vietnamese Cohorts.

Nguyen QG et al.

Balkan Journal of Medical Genetics : Bjmg, 2025

Computational pharmacogenotype extraction from clinical next-generation sequencing.

Shugg T et al.

Frontiers in Oncology, 2023

Pharmacogenomics biomarkers for personalized methadone maintenance treatment: The mechanism and its potential use.

Ramli FF

Bosnian Journal of Basic Medical Sciences, 2021

Severe and prolonged cyclophosphamide-induced hepatotoxicity in a breast cancer patient carrying a CYP2B6*7 variant.

Ming Z et al.

Pharmacogenomics, 2019

Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics.

Ahmad T et al.

Biochemical Pharmacology, 2018

CYP2B6rs2279343 Is Associated with Improved Survival of Pediatric Rhabdomyosarcoma Treated with Cyclophosphamide.

Labib RM et al.

Plos One, 2016

Effects of CYP2B6 genetic polymorphisms in patients receiving cyclophosphamide combination chemotherapy for breast cancer.

Haroun F et al.

Cancer Chemotherapy and Pharmacology, 2015

CYP2B6 haplotype and biological factors responsible for hepatotoxicity in HIV-infected patients receiving efavirenz-based antiretroviral therapy.

Manosuthi W et al.

International Journal of Antimicrobial Agents, 2014

Pharmacometric characterization of efavirenz developmental pharmacokinetics and pharmacogenetics in HIV-infected children.

Salem AH et al.

Antimicrobial Agents and Chemotherapy, 2014

CYP2B6 SNPs are associated with methadone dose required for effective treatment of opioid addiction.

Levran O et al.

Addiction Biology, 2013

Analysis of pharmacogenetic traits in two distinct South African populations.

Ikediobi O et al.

Human Genomics, 2011

Haplotype structure and allele frequencies of CYP2B6 in Spaniards and Central Americans.

Arenaz I et al.

Fundamental & Clinical Pharmacology, 2010

Influence of pharmacogenetics on response and toxicity in breast cancer patients treated with doxorubicin and cyclophosphamide.

Bray J et al.

British Journal of Cancer, 2010

Efavirenz induces CYP2B6-mediated hydroxylation of bupropion in healthy subjects.

Robertson SM et al.

Journal of Acquired Immune Deficiency Syndromes (1999), 2008

Do single nucleotide polymorphisms in xenobiotic metabolizing genes determine breast cancer susceptibility and treatment outcomes?

Singh V et al.

Cancer Investigation, 2008

Genetic polymorphisms of CYP2B6 affect the pharmacokinetics/pharmacodynamics of cyclophosphamide in Japanese cancer patients.

Nakajima M et al.

Pharmacogenetics and Genomics, 2007

Genetic polymorphisms of cytochrome P450 2B6 gene in Han Chinese.

Guan S et al.

European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences, 2006

Identification of a novel specific CYP2B6 allele in Africans causing impaired metabolism of the HIV drug efavirenz.

Wang J et al.

Pharmacogenetics and Genomics, 2006

Methadone enantiomer plasma levels, CYP2B6, CYP2C19, and CYP2C9 genotypes, and response to treatment.

Crettol S et al.

Clinical Pharmacology and Therapeutics, 2005

Homozygous CYP2B6 *6 (Q172H and K262R) correlates with high plasma efavirenz concentrations in HIV-1 patients treated with standard efavirenz-containing regimens.

Tsuchiya K et al.

Biochemical and Biophysical Research Communications, 2004

Pharmacogenetics in HIV therapy.

Rodríguez-Nóvoa S et al.

Aids Reviews, 0

Overview of the pharmacogenetics of HIV therapy.

Rodríguez-Nóvoa S et al.

The Pharmacogenomics Journal, 0

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."