Varaico: Literature-Extracted Genetic Variants

Gene:CYP4F2
Variant:p.V433M
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CYP4F2

NM_001082.5:p.V433M

Associated Papers

Clinical Application of Pharmacogenomics in Stroke Management: Current Evidence and Future Directions.

Lee KJ et al.

Journal of Stroke, 2026

The association of Cytochrome 4F2 rs2108622 genetic variant and non-genetic factors with essential hypertension among Jordanian patients attending the University of Jordan Hospital.

Alkasasbeh EY et al.

Prostaglandins & Other Lipid Mediators, 2025

Genome-wide screening of pharmacogenomic biomarkers in jordanian patients with genetic disorders.

Jarrar Y et al.

The Pharmacogenomics Journal, 2025

Predictor Role of VKORC1 rs9923231, CYP4F2 rs2108622, and GGCX rs11676382 Polymorphisms of 5 Years Mortality of Patients with Acute Ischemic Stroke.

Iluţ S et al.

Medicina (kaunas, Lithuania), 2025

Molecular Determinants of the Human Retinal Pigment Epithelium Cell Fate and Potential Pharmacogenomic Targets for Precision Medicine.

Zibetti C

International Journal of Molecular Sciences, 2025

40565279 (PubMed )
Supplement: ijms-26-05817-s001.zip › Table_S1_NGS_qc_and_WES_April2025_2_.xlsx › D2_hiPSCsvsPBMC_SNPs_InDels

Genetic Variability of CYP4F2, CYP2D6, CYP2E1, and ACE in the Chinese Yi Population.

Guo J et al.

Biochemical Genetics, 2025

Contrastive sequence signatures between the both sides of a recombination spot reveal an adaptation at PPARD locus from standing variation for pleiotropy since out-of-Africa dispersal.

Shou W et al.

Bmc Genomics, 2025

40307732 (PubMed )
Supplement: 12864_2025_11620_MOESM2_ESM.xlsx › TS5

Endogamy and high prevalence of deleterious mutations in India: evidence from strong founder events.

Machha P et al.

Journal of Genetics and Genomics = Yi Chuan Xue Bao, 2025

The pharmacogenomic landscape in the Chinese: An analytics of pharmacogenetic variants in 206,640 individuals.

Wang LY et al.

Innovation (cambridge (mass.)), 2025

39991480 (PubMed )
Supplement: mmc5.xlsx › Sheet1

The impact of genetic variability on Alzheimer's therapies: obstacles for pharmacogenetic progress.

Cacabelos R et al.

Expert Opinion on Drug Metabolism & Toxicology, 2025

Exome sequencing reveals a rare damaging variant in GRIN2C in familial late-onset Alzheimer's disease.

Rubino E et al.

Alzheimer's Research & Therapy, 2025

39810256 (PubMed )
Supplement: 13195_2024_1661_MOESM2_ESM.xlsx › Suppl._Table_2

Genome-wide association study reveals shared and distinct genetic architecture of fatty acids and oxylipins in the Hispanic Community Health Study/Study of Latinos.

Downie CG et al.

Hgg Advances, 2025

Value of Pharmacogenetic Testing Assessed with Real-World Drug Utilization and Genotype Data.

Litonius K et al.

Clinical Pharmacology and Therapeutics, 2025

39365028 (PubMed )
Supplement: CPT-117-278-s001.pdf

Pharmacodynamic Modeling of Warfarin Dosing Algorithm for Cardiovascular Patients in Indonesia: A Tailored Method to Anticoagulation Therapy.

Putriana NA et al.

Drug Design, Development and Therapy, 2025

The impact of CYP2C9, VKORC1, and CYP4F2 polymorphisms on warfarin dose requirement in Saudi patients.

Jokhab S et al.

Frontiers in Pharmacology, 2025

Pharmacogenomics and genetic ancestry in Colombia: a study on all variant drug annotations of PharmGKB.

Acosta-Monterrosa AA et al.

Frontiers in Pharmacology, 2025

40949159 (PubMed )
Supplement: Table1.xlsx › Studies

Application of rapid genotyping of Warfarin individualized pharmacogenetic variants in Warfarin therapy.

Huang D et al.

Scientific Reports, 2024

Phenotype driven molecular genetic test recommendation for diagnosing pediatric rare disorders.

Chen F et al.

Npj Digital Medicine, 2024

39572625 (PubMed )
Supplement: 41746_2024_1331_MOESM2_ESM.xlsx › Supplementary_Data_6

PharmVar GeneFocus: CYP4F2.

Zubiaur P et al.

Clinical Pharmacology and Therapeutics, 2024

Lipidomic biomarkers in plasma correlate with disease severity in adrenoleukodystrophy.

Jaspers YRJ et al.

Communications Medicine, 2024

Leveraging QSP Models for MIPD: A Case Study for Warfarin/INR.

Falkenhagen U et al.

Clinical Pharmacology and Therapeutics, 2024

Four-dimensional lipidomics profiling in X-linked adrenoleukodystrophy using trapped ion mobility mass spectrometry.

Jaspers YRJ et al.

Journal of Lipid Research, 2024

Precision medicine in cardiovascular therapeutics: Evaluating the role of pharmacogenetic analysis prior to drug treatment.

Ingelman-Sundberg M et al.

Journal of Internal Medicine, 2024

ACE Phenotyping in Human Blood and Tissues: Revelation of ACE Outliers and Sex Differences in ACE Sialylation.

Enyedi EE et al.

Biomedicines, 2024

38790902 (PubMed )
Supplement: biomedicines-12-00940-s001.zip › biomedicines-2930173-supplementary.pdf

Cytochrome P450 Family 4F2 and 4F11 Haplotype Mapping and Association with Hepatic Gene Expression and Vitamin K Hydroxylation Activity.

Alade AN et al.

Acs Pharmacology & Translational Science, 2024

Utility of Cytochrome P450 4F2 Genotyping to Assess Drug Interaction Risk for Brincidovovir, a Cytochrome P450 4F2 Substrate.

Tippin T et al.

Clinical Pharmacology in Drug Development, 2024

Effect of donor GSTM3 rs7483 genetic variant on tacrolimus elimination in the early period after liver transplantation.

Zhang T et al.

Peerj, 2024

39465171 (PubMed )
Supplement: peerj-12-18360-s002.7z › drug-metabolizing_enzymes_and_transporter__DMET__microarray › markerlist.xlsx › markerlist.TXT

Pharmacogenomic Considerations for Anticoagulant Prescription in Patients with Hereditary Haemorrhagic Telangiectasia.

McCarley SC et al.

Journal of Clinical Medicine, 2023

38137783 (PubMed )
Supplement: jcm-12-07710-s001.zip › jcm-2746832-supplementary.pdf

Functional Characterization of 29 Cytochrome P450 4F2 Variants Identified in a Population of 8380 Japanese Subjects and Assessment of Arachidonic Acid ω-Hydroxylation.

Sato Y et al.

Drug Metabolism and Disposition: the Biological Fate of Chemicals, 2023

Indicators of HSV1 Infection, ECM-Receptor Interaction, and Chromatin Modulation in a Nuclear Family with Schizophrenia.

Huang YC et al.

Journal of Personalized Medicine, 2023

37763159 (PubMed )
Supplement: jpm-13-01392-s001.zip › Supplementary_Table_S3.xlsx › Variants

Whole-genome sequencing across 449 samples spanning 47 ethnolinguistic groups provides insights into genetic diversity in Nigeria.

Joshi E et al.

Cell Genomics, 2023

37719143 (PubMed )
Supplement: mmc6.pdf

Association of CYP4A22 gene polymorphisms with cerebral stroke risk in the Chinese Han population.

Zhuo Q et al.

The Journal of Gene Medicine, 2023

Frequency of polymorphisms in the CYP2C9, VKORC1, and CYP4F2 genes related to the metabolism of Warfarin in healthy donors from Cali, Colombia.

Giraldo-Ocampo S et al.

Medicine, 2023

Efficacy of Warfarin Therapy Guided by Pharmacogenetics: A Real-world Investigation Among Han Taiwanese.

Liu TY et al.

Clinical Therapeutics, 2023

Evaluation of a warfarin dosing algorithm including CYP2C9, VKORC1, and CYP4F2 polymorphisms and non-genetic determinants for the Iranian population.

Farajzadeh-Dehkordi M et al.

Pharmacological Reports : Pr, 2023

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.

Tanzo JT et al.

The Journal of Biological Chemistry, 2023

Genetic Factors Influencing Warfarin Dose in Han Chinese Population: A Systematic Review and Meta-Analysis of Cohort Studies.

Zhao Z et al.

Clinical Pharmacokinetics, 2023

Computational analysis of missense variant CYP4F2*3 (V433M) in association with human CYP4F2 dysfunction: a functional and structural impact.

Farajzadeh-Dehkordi M et al.

Bmc Molecular and Cell Biology, 2023

Insights into the binding mechanism between α-TOH and CYP4F2: A homology modeling, molecular docking, and molecular dynamics simulation study.

Liang L et al.

Journal of Cellular Biochemistry, 2023

CYP4F2 is a human-specific determinant of circulating N-acyl amino acid levels.

Tanzo JT et al.

Biorxiv : the Preprint Server for Biology, 2023

Pharmacogenetics of anxiety and depression in Alzheimer's disease.

Cacabelos R et al.

Pharmacogenomics, 2023

Characterization of pharmacogenomic variants in a Brazilian admixed cohort of elderly individuals based on whole-genome sequencing data.

Bertholim-Nasciben L et al.

Frontiers in Pharmacology, 2023

The pharmacogenomic landscape of an Indigenous Australian population.

Samarasinghe SR et al.

Frontiers in Pharmacology, 2023

37284308 (PubMed )
Supplement: Table3.xlsx › HE_SNPs

One Rare Warfarin Resistance Case and Possible Mechanism Exploration.

Zhao L et al.

Pharmacogenomics and Personalized Medicine, 2023

Targeted haplotyping in pharmacogenomics using Oxford Nanopore Technologies' adaptive sampling.

Deserranno K et al.

Frontiers in Pharmacology, 2023

38026945 (PubMed )
Supplement: DataSheet1.ZIP › SupplementaryMaterials › SupplementaryMaterials_Tables_S4-S9.xlsx › HG00190_R10.4.1_AldyCalls
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."