Varaico: Literature-Extracted Genetic Variants

Gene:DHFR
Variant:p.D146G
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DHFR

NM_000791.4:p.D146G

Associated Papers

Prevalence of Plasmodium falciparum parasites harbouring chloroquine-resistant but not artemisinin-resistant alleles in Busia County, Western Kenya.

Onchieku NM et al.

Malaria Journal, 2025

Very low prevalence of validated kelch13 mutations and absence of hrp2/3 double gene deletions in South African malaria-eliminating districts (2022-2024).

Raman J et al.

Medrxiv : the Preprint Server for Health Sciences, 2025

Detection of low frequency artemisinin resistance mutations, C469Y, P553L and A675V, and fixed antifolate resistance mutations in asymptomatic primary school children in Kenya.

Osoti V et al.

Bmc Infectious Diseases, 2025

A retrospective analysis of P. falciparum drug resistance markers detects an early (2016/17) high prevalence of the k13 C469Y mutation in asymptomatic infections in Northern Uganda.

Ogwang R et al.

Antimicrobial Agents and Chemotherapy, 2024

National genomic profiling of Plasmodium falciparum antimalarial resistance in Zambian children participating in the 2018 Malaria Indicator Survey.

Fola AA et al.

Medrxiv : the Preprint Server for Health Sciences, 2024

Limited Polymorphism in the Dihydrofolate Reductase (dhfr) and dihydropteroate synthase genes (dhps) of Plasmodium knowlesi isolate from Thailand.

Sangsri R et al.

Acta Tropica, 2023

The landscape of drug resistance in Plasmodium falciparum malaria in the Democratic Republic of Congo: a mapping systematic review.

Kayiba NK et al.

Tropical Medicine and Health, 2023

Assessment of genetic polymorphisms associated with malaria antifolate resistance among the population of Libreville, Gabon.

Dinzouna-Boutamba SD et al.

Malaria Journal, 2023

A snapshot of the prevalence of dihydropteroate synthase-431V mutation and other sulfadoxine-pyrimethamine resistance markers in Plasmodium falciparum isolates in Nigeria.

Adegbola AJ et al.

Malaria Journal, 2023

Global Analysis of Plasmodium falciparum Dihydropteroate Synthase Variants Associated with Sulfadoxine Resistance Reveals Variant Distribution and Mechanisms of Resistance: A Computational-Based Study.

Boateng RA et al.

Molecules (basel, Switzerland), 2022

Drug resistance of Plasmodium falciparum and Plasmodium vivax isolates in Indonesia.

Rahmasari FV et al.

Malaria Journal, 2022

Molecular surveillance for anti-malarial drug resistance and genetic diversity of Plasmodium falciparum after chloroquine and sulfadoxine-pyrimethamine withdrawal in Quibdo, Colombia, 2018.

Guerra AP et al.

Malaria Journal, 2022

Targeted Amplicon Deep Sequencing for Monitoring Antimalarial Resistance Markers in Western Kenya.

Osoti V et al.

Antimicrobial Agents and Chemotherapy, 2022

Distinct pattern and prevalence of Plasmodium falciparum dihydropteroate synthase gene mutations in children with sickle cell anaemia and haemoglobin AA in Benin City, Nigeria: the impact of HbAA.

Enato IG et al.

The Pan African Medical Journal, 2022

Increased prevalence of pfdhfr and pfdhps mutations associated with sulfadoxine-pyrimethamine resistance in Plasmodium falciparum isolates from Jazan Region, Southwestern Saudi Arabia: important implications for malaria treatment policy.

Madkhali AM et al.

Malaria Journal, 2020

Molecular surveillance of anti-malarial resistance Pfdhfr and Pfdhps polymorphisms in African and Southeast Asia Plasmodium falciparum imported parasites to Wuhan, China.

Jiang T et al.

Malaria Journal, 2020

Stable high frequencies of sulfadoxine-pyrimethamine resistance associated mutations and absence of K13 mutations in Plasmodium falciparum 3 and 4 years after the introduction of artesunate plus sulfadoxine-pyrimethamine in Ujjain, Madhya Pradesh, India.

Pathak A et al.

Malaria Journal, 2020

Widespread resistance mutations to sulfadoxine-pyrimethamine in malaria parasites imported to China from Central and Western Africa.

Zhao L et al.

International Journal for Parasitology. Drugs and Drug Resistance, 2020

Assessment of Plasmodium falciparum drug resistance molecular markers from the Blue Nile State, Southeast Sudan.

Mohamed AO et al.

Malaria Journal, 2020

Antimalarial drug resistance molecular makers of Plasmodium falciparum isolates from Sudan during 2015-2017.

Hussien M et al.

Plos One, 2020

Structure of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase-dihydropteroate synthase from Plasmodium vivax sheds light on drug resistance.

Yogavel M et al.

The Journal of Biological Chemistry, 2018

Nanopore sequencing of drug-resistance-associated genes in malaria parasites, Plasmodium falciparum.

Runtuwene LR et al.

Scientific Reports, 2018

29844487 (PubMed )
Supplement: 41598_2018_26334_MOESM1_ESM.docx

Molecular identification of sulfadoxine-pyrimethamine resistance in malaria infected women who received intermittent preventive treatment in the Democratic Republic of Congo.

Ruh E et al.

Malaria Journal, 2018

Recent uptake of intermittent preventive treatment during pregnancy with sulfadoxine-pyrimethamine is associated with increased prevalence of Pfdhfr mutations in Bobo-Dioulasso, Burkina Faso.

Cisse M et al.

Malaria Journal, 2017

Prevalence of anti-malarial resistance genes in Dakar, Senegal from 2013 to 2014.

Boussaroque A et al.

Malaria Journal, 2016

Low-grade sulfadoxine-pyrimethamine resistance in Plasmodium falciparum parasites from Lubango, Angola.

Kaingona-Daniel EP et al.

Malaria Journal, 2016

Increased Prevalence of Mutant Allele Pfdhps 437G and Pfdhfr Triple Mutation in Plasmodium falciparum Isolates from a Rural Area of Gabon, Three Years after the Change of Malaria Treatment Policy.

Ndong Ngomo JM et al.

Malaria Research and Treatment, 2016

Prevalence of Plasmodium falciparum parasites resistant to sulfadoxine/pyrimethamine in pregnant women in Yaoundé, Cameroon: emergence of highly resistant pfdhfr/pfdhps alleles.

Chauvin P et al.

The Journal of Antimicrobial Chemotherapy, 2015

Prevalence of the dhfr and dhps Mutations among Pregnant Women in Rural Burkina Faso Five Years after the Introduction of Intermittent Preventive Treatment with Sulfadoxine-Pyrimethamine.

Tahita MC et al.

Plos One, 2015

Declining trend of Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant alleles after the withdrawal of Sulfadoxine-Pyrimethamine in North Western Ethiopia.

Tessema SK et al.

Plos One, 2015

Novel Mutation in Cytochrome B of Plasmodium falciparum in One of Two Atovaquone-Proguanil Treatment Failures in Travelers Returning From Same Site in Nigeria.

Plucinski MM et al.

Open Forum Infectious Diseases, 2014

Malaria treatment failure with novel mutation in the Plasmodium falciparum dihydrofolate reductase (pfdhfr) gene in Kolkata, West Bengal, India.

Das S et al.

International Journal of Antimicrobial Agents, 2013

Molecular epidemiology of drug resistance markers of Plasmodium falciparum in Yunnan Province, China.

Huang F et al.

Malaria Journal, 2012

Molecular analysis of markers associated with chloroquine and sulfadoxine/pyrimethamine resistance in Plasmodium falciparum malaria parasites from southeastern Côte-d'Ivoire by the time of Artemisinin-based Combination Therapy adoption in 2005.

Ako BA et al.

Infection and Drug Resistance, 2012

Anti-folate drug resistance in Africa: meta-analysis of reported dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) mutant genotype frequencies in African Plasmodium falciparum parasite populations.

Sridaran S et al.

Malaria Journal, 2010

Novel point mutations in sulfadoxine resistance genes of Plasmodium falciparum from India.

Garg S et al.

Acta Tropica, 2009

Emergence of a dhfr mutation conferring high-level drug resistance in Plasmodium falciparum populations from southwest Uganda.

Lynch C et al.

The Journal of Infectious Diseases, 2008

[Antimalarial drug resistance].

Le Bras J et al.

Medecine Et Maladies Infectieuses, 2006

Molecular determination of point mutation haplotypes in the dihydrofolate reductase and dihydropteroate synthase of Plasmodium falciparum in three districts of northern Tanzania.

Pearce RJ et al.

Antimicrobial Agents and Chemotherapy, 2003

Prevalence of multiple drug-resistant Plasmodium falciparum malaria cases in Northeast India.

Sharma J et al.

Indian Journal of Medical Microbiology, 0

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