Varaico: Literature-Extracted Genetic Variants

Gene:DHFR
Variant:p.E45K
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DHFR

NM_000791.4:p.E45K

Associated Papers

Residues 45 and 404 in the murine reduced folate carrier may interact to alter carrier binding and mobility.

Zhao R et al.

Biochimica Et Biophysica Acta, 2003

Reduced folate carrier: biochemistry and molecular biology of the normal and methotrexate-resistant cell.

Bosson G

British Journal of Biomedical Science, 2003

Role of the E45K-reduced folate carrier gene mutation in methotrexate resistance in human leukemia cells.

Gifford AJ et al.

Leukemia, 2002

Mutational analysis of the functional role of conserved arginine and lysine residues in transmembrane domains of the murine reduced folate carrier.

Sharina IG et al.

Molecular Pharmacology, 2001

Discrimination among reduced folates and methotrexate as transport substrates by a phenylalanine substitution for serine within the predicted eighth transmembrane domain of the reduced folate carrier.

Zhao R et al.

Biochemical Pharmacology, 1999

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."