Varaico: Literature-Extracted Genetic Variants

Gene:DIS3
Variant:p.D487N
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DIS3

NM_014953.5:p.D487N

Associated Papers

Distinct and evolutionary conserved structural features of the human nuclear exosome complex.

Gerlach P et al.

Elife, 2018

Genomic profiling is predictive of response to cisplatin treatment but not to PI3K inhibition in bladder cancer patient-derived xenografts.

Wei L et al.

Oncotarget, 2016

27823983 (PubMed )
Supplement: oncotarget-07-76374-s002.xlsx › 2

DIS3 shapes the RNA polymerase II transcriptome in humans by degrading a variety of unwanted transcripts.

Szczepińska T et al.

Genome Research, 2015

A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias.

Lionetti M et al.

Oncotarget, 2015

The 3' to 5' Exoribonuclease DIS3: From Structure and Mechanisms to Biological Functions and Role in Human Disease.

Robinson SR et al.

Biomolecules, 2015

Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target.

Tomecki R et al.

Nucleic Acids Research, 2014

The human core exosome interacts with differentially localized processive RNases: hDIS3 and hDIS3L.

Tomecki R et al.

The Embo Journal, 2010

20531386 (PubMed )
Supplement: 44318_2010_BFEMBJ2010121_MOESM1_ESM.pdf
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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."