Associated Papers
Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models.
Volgin AD et al.
Journal of Integrative Neuroscience, 2025
Common DISC1 Polymorphisms Disrupt Wnt/GSK3β Signaling and Brain Development.
Singh KK et al.
Neuron, 2025
3-Dimensional structure prediction of C-terminal disrupted in schizophrenia 1: a suspected culprit of schizophrenia.
Khan MQ et al.
Journal of Biomolecular Structure & Dynamics, 2025
Identification and Mechanistic Characterization of a Peptide Inhibitor of Glycogen Synthase Kinase (GSK3β) Derived from the Disrupted in Schizophrenia 1 (DISC1) Protein.
Saundh SL et al.
Acs Chemical Neuroscience, 2020
Disrupted-in-schizophrenia 1 functional polymorphisms and D2 /D3 receptor availability: A [11 C]-(+)-PHNO imaging study.
Dahoun T et al.
Genes, Brain, and Behavior, 2019
A DISC1 point mutation promotes oligomerization and impairs information processing in a mouse model of schizophrenia.
Kakuda K et al.
Journal of Biochemistry, 2019
Association study of Disrupted-In-Schizophrenia-1 gene variants and tardive dyskinesia.
Lu JY et al.
Neuroscience Letters, 2018
The association between gene variants and longitudinal structural brain changes in psychosis: a systematic review of longitudinal neuroimaging genetics studies.
Harari JH et al.
Npj Schizophrenia, 2017
The relationship between genetic risk variants with brain structure and function in bipolar disorder: A systematic review of genetic-neuroimaging studies.
Pereira LP et al.
Neuroscience and Biobehavioral Reviews, 2017
Additive sex-specific influence of common non-synonymous DISC1 variants on amygdala, basal ganglia, and white cortical surface area in healthy young adults.
Mühle C et al.
Brain Structure & Function, 2017
TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology.
Chen CY et al.
Embo Reports, 2017
Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits.
Trossbach SV et al.
Molecular Psychiatry, 2016
Variations in Disrupted-in-Schizophrenia 1 gene modulate long-term longitudinal differences in cortical thickness in patients with a first-episode of psychosis.
Vázquez-Bourgon J et al.
Brain Imaging and Behavior, 2016
DISC1 causes associative memory and neurodevelopmental defects in fruit flies.
Furukubo-Tokunaga K et al.
Molecular Psychiatry, 2016
Effect of DISC1 polymorphisms on the long-term course of neurocognitive deficits in non-affective psychosis.
Vázquez-Bourgon J et al.
European Psychiatry : the Journal of the Association of European Psychiatrists, 2015
Functional genomics indicate that schizophrenia may be an adult vascular-ischemic disorder.
Moises HW et al.
Translational Psychiatry, 2015
DISC1 regulates trafficking and processing of APP and Aβ generation.
Shahani N et al.
Molecular Psychiatry, 2015
DISC1 Ser704Cys impacts thalamic-prefrontal connectivity.
Liu B et al.
Brain Structure & Function, 2015
A brain-wide association study of DISC1 genetic variants reveals a relationship with the structure and functional connectivity of the precuneus in schizophrenia.
Gong X et al.
Human Brain Mapping, 2014
DISC1-TSNAX and DAOA genes in major depression and citalopram efficacy.
Arias B et al.
Journal of Affective Disorders, 2014
708 Common and 2010 rare DISC1 locus variants identified in 1542 subjects: analysis for association with psychiatric disorder and cognitive traits.
Thomson PA et al.
Molecular Psychiatry, 2014
A Disrupted-in-Schizophrenia 1 Gene Variant is Associated with Clinical Symptomatology in Patients with First-Episode Psychosis.
Vázquez-Bourgon J et al.
Psychiatry Investigation, 2014
Transmission disequilibrium of DISC1 haplotypes in Bulgarian families with affective disorder.
Ivanova MA et al.
Psychiatry Research, 2013
Lack of association between DISC1 polymorphisms and risk of schizophrenia in a Korean population.
Bae JS et al.
Psychiatry Research, 2013
Less efficient information transfer in Cys-allele carriers of DISC1: a brain network study based on diffusion MRI.
Li Y et al.
Cerebral Cortex (new York, N.y. : 1991), 2013
Human brain imaging studies of DISC1 in schizophrenia, bipolar disorder and depression: a systematic review.
Duff BJ et al.
Schizophrenia Research, 2013
DISC1 in adult ADHD patients: an association study in two European samples.
Jacobsen KK et al.
American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics, 2013
DISC1 (disrupted-in-schizophrenia 1) is associated with cortical grey matter volumes in the human brain: a voxel-based morphometry (VBM) study.
Trost S et al.
Journal of Psychiatric Research, 2013
Progress in imaging the effects of psychosis susceptibility gene variants.
Redpath HL et al.
Expert Review of Neurotherapeutics, 2013
A t(1;11) translocation linked to schizophrenia and affective disorders gives rise to aberrant chimeric DISC1 transcripts that encode structurally altered, deleterious mitochondrial proteins.
Eykelenboom JE et al.
Human Molecular Genetics, 2012
Gender-specific association of TSNAX/DISC1 locus for schizophrenia and bipolar affective disorder in South Indian population.
Ram Murthy A et al.
Journal of Human Genetics, 2012
DISC1 variants 37W and 607F disrupt its nuclear targeting and regulatory role in ATF4-mediated transcription.
Malavasi EL et al.
Human Molecular Genetics, 2012
The effect of DISC1 on regional gray matter density of schizophrenia in Han Chinese population.
Wei Q et al.
Neuroscience Letters, 2012
Annual research review: impact of advances in genetics in understanding developmental psychopathology.
Addington AM et al.
Journal of Child Psychology and Psychiatry, and Allied Disciplines, 2012
DISC1-binding proteins in neural development, signalling and schizophrenia.
Bradshaw NJ et al.
Neuropharmacology, 2012
DISC1 and Striatal Volume: A Potential Risk Phenotype For mental Illness.
Chakravarty MM et al.
Frontiers in Psychiatry, 2012
Molecular characterization of disrupted in schizophrenia-1 risk variant S704C reveals the formation of altered oligomeric assembly.
Narayanan S et al.
The Journal of Biological Chemistry, 2011
Common DISC1 polymorphisms disrupt Wnt/GSK3β signaling and brain development.
Singh KK et al.
Neuron, 2011
Structure and evolutionary history of DISC1.
Sanchez-Pulido L et al.
Human Molecular Genetics, 2011
Common functional polymorphisms of DISC1 and cortical maturation in typically developing children and adolescents.
Raznahan A et al.
Molecular Psychiatry, 2011
DISC1 is associated with cortical thickness and neural efficiency.
Brauns S et al.
Neuroimage, 2011
Association of Disrupted in Schizophrenia 1 (DISC1) missense variants with ultra-resistant schizophrenia.
Mouaffak F et al.
The Pharmacogenomics Journal, 2011
Genetic and functional analyses identify DISC1 as a novel callosal agenesis candidate gene.
Osbun N et al.
American Journal of Medical Genetics. Part A, 2011
The effects of DISC1 risk variants on brain activation in controls, patients with bipolar disorder and patients with schizophrenia.
Chakirova G et al.
Psychiatry Research, 2011
No association of Disrupted-in-Schizophrenia-1 variation with prefrontal function in patients with schizophrenia and bipolar disorder.
Prata DP et al.
Genes, Brain, and Behavior, 2011
Association study between Disrupted-in-Schizophrenia-1 (DISC1) and Japanese patients with treatment-resistant schizophrenia (TRS).
Hotta Y et al.
Progress in Neuro-psychopharmacology & Biological Psychiatry, 2011
DISC1 in schizophrenia: genetic mouse models and human genomic imaging.
Johnstone M et al.
Schizophrenia Bulletin, 2011
Identification of high risk DISC1 protein structural variants in patients with bipolar spectrum disorder.
Song W et al.
Neuroscience Letters, 2010
Association of DISC1 gene with schizophrenia in families from two distinct French and Algerian populations.
Lepagnol-Bestel AM et al.
Psychiatric Genetics, 2010