Associated Papers
DNA2 enables growth by restricting recombination-restarted replication.
Hudson JJR et al.
Nature, 2025
Dynamic control of RNA-DNA hybrid formation orchestrates DNA2 activation at stalled forks by RNAPII and DDX39A.
Song L et al.
Molecular Cell, 2025
Mechanism of BRCA1-BARD1 function in DNA end resection and DNA protection.
Ceppi I et al.
Nature, 2024
BLM helicase unwinds lagging strand substrates to assemble the ALT telomere damage response.
Jiang H et al.
Molecular Cell, 2024
The MRN complex and topoisomerase IIIa-RMI1/2 synchronize DNA resection motor proteins.
Soniat MM et al.
The Journal of Biological Chemistry, 2023
The nuclease activity of DNA2 promotes exonuclease 1-independent mismatch repair.
Kadyrova LY et al.
The Journal of Biological Chemistry, 2022
The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2.
Mariotti L et al.
Communications Biology, 2020
BLM has Contrary Effects on Repeat-Mediated Deletions, based on the Distance of DNA DSBs to a Repeat and Repeat Divergence.
Mendez-Dorantes C et al.
Cell Reports, 2020
Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases.
Pinto C et al.
Elife, 2016
A Selective Small Molecule DNA2 Inhibitor for Sensitization of Human Cancer Cells to Chemotherapy.
Liu W et al.
Ebiomedicine, 2016
27211550 (PubMed )
Supplement: mmc1.pdf
Multifaceted role of the Topo IIIα-RMI1-RMI2 complex and DNA2 in the BLM-dependent pathway of DNA break end resection.
Daley JM et al.
Nucleic Acids Research, 2014
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