Varaico: Literature-Extracted Genetic Variants

Gene:DNMT3A
Variant:p.D781G
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DNMT3A

NM_022552.5:p.D781G

Associated Papers

Impact of Carrying DNMT3A or TET2 Mutations on Plaque Characteristics and Prognosis in Patients With STEMI Based on OCT.

Sun Q et al.

Circulation. Cardiovascular Imaging, 2025

40755316 (PubMed )
Supplement: circcvim-2024-017915-s03.pdf

Increased local DNA methylation disorder in AMLs with DNMT3A-destabilizing variants and its clinical implication.

Lee D et al.

Nature Communications, 2025

39794314 (PubMed )
Supplement: 41467_2024_55691_MOESM8_ESM.xlsx › Fig._1i_1h

Impact of cancer therapy on clonal hematopoiesis mutations and subsequent clinical outcomes.

Nead KT et al.

Blood Advances, 2024

38830141 (PubMed )
Supplement: BLOODA_ADV-2024-012929-mmc1.xlsx › STable_2

Cancer-driving mutations are enriched in genic regions intolerant to germline variation.

Vitsios D et al.

Science Advances, 2022

36026442 (PubMed )
Supplement: sciadv.abo6371_tables_s1_to_s13.zip › sciadv.abo6371_tables_s1_to_s13.xlsx › S4

Systematic Profiling of DNMT3A Variants Reveals Protein Instability Mediated by the DCAF8 E3 Ubiquitin Ligase Adaptor.

Huang YH et al.

Cancer Discovery, 2022

34429321 (PubMed )
Supplement: cd-21-0560_supplementary_table_1_suppst1.xlsx › Sheet1

Functional Analysis of DNMT3A DNA Methyltransferase Mutations Reported in Patients with Acute Myeloid Leukemia.

Khrabrova DA et al.

Biomolecules, 2019

Epigenetic Enzyme Mutations: Role in Tumorigenesis and Molecular Inhibitors.

Han M et al.

Frontiers in Oncology, 2019

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.

Klco JM et al.

Cancer Cell, 2014

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."