Associated Papers
Structural insight into hierarchical DNMT3A autoinhibition and its dysregulation in disease.
Lu J et al.
Nature Communications, 2026
Convergent DNA methylation abnormalities at enhancers and bivalent promoters in human growth disorders.
Wheeler MES et al.
Epigenetics & Chromatin, 2025
Recurrent carotid paragangliomas in a syndromic patient with a heterozygous missense variant in DNA Methyltransferase 3 Alpha.
German RJ et al.
American Journal of Medical Genetics. Part A, 2025
The N-terminal region of DNMT3A engages the nucleosome surface to aid chromatin recruitment.
Wapenaar H et al.
Embo Reports, 2024
Using human disease mutations to understand de novo DNA methyltransferase function.
Rolls W et al.
Biochemical Society Transactions, 2024
Cancer-associated DNA hypermethylation of Polycomb targets requires DNMT3A dual recognition of histone H2AK119 ubiquitination and the nucleosome acidic patch.
Gretarsson KH et al.
Science Advances, 2024
Clinical Case of Mild Tatton-Brown-Rahman Syndrome Caused by a Nonsense Variant in DNMT3A Gene.
Bostanova F et al.
Clinics and Practice, 2024
DNMT3B PWWP mutations cause hypermethylation of heterochromatin.
Taglini F et al.
Embo Reports, 2024
Diverse Molecular Mechanisms Underlying Pathogenic Protein Mutations: Beyond the Loss-of-Function Paradigm.
Backwell L et al.
Annual Review of Genomics and Human Genetics, 2022
Two competing mechanisms of DNMT3A recruitment regulate the dynamics of de novo DNA methylation at PRC1-targeted CpG islands.
Weinberg DN et al.
Nature Genetics, 2021
The DNMT3A PWWP domain is essential for the normal DNA methylation landscape in mouse somatic cells and oocytes.
Kibe K et al.
Plos Genetics, 2021
Alterations to DNMT3A in Hematologic Malignancies.
Venugopal K et al.
Cancer Research, 2021
H3K36me2/3 Binding and DNA Binding of the DNA Methyltransferase DNMT3A PWWP Domain Both Contribute to its Chromatin Interaction.
Dukatz M et al.
Journal of Molecular Biology, 2019
Understanding histone H3 lysine 36 methylation and its deregulation in disease.
Li J et al.
Cellular and Molecular Life Sciences : Cmls, 2019
Effect of Disease-Associated Germline Mutations on Structure Function Relationship of DNA Methyltransferases.
Norvil AB et al.
Genes, 2019
Gain-of-function DNMT3A mutations cause microcephalic dwarfism and hypermethylation of Polycomb-regulated regions.
Heyn P et al.
Nature Genetics, 2019
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