Varaico: Literature-Extracted Genetic Variants

Gene:DPYS
Variant:p.R412R
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DPYS

NM_001385.3:p.R412R

Associated Papers

DPYD genotype-guided dose personalisation for fluoropyrimidine-based chemotherapy prescribing in solid organ cancer patients in Australia: GeneScreen 5-FU study protocol.

White C et al.

Bmc Cancer, 2024

Influence of Single-Nucleotide Polymorphisms on Clinical Outcomes of Capecitabine-Based Chemotherapy in Colorectal Cancer Patients: A Systematic Review.

Cura Y et al.

Cancers, 2023

Current diagnostic and clinical issues of screening for dihydropyrimidine dehydrogenase deficiency.

Etienne-Grimaldi MC et al.

European Journal of Cancer (oxford, England : 1990), 2023

Dihydropyrimidine Dehydrogenase Deficiency and Implementation of Upfront DPYD Genotyping.

White C et al.

Clinical Pharmacology and Therapeutics, 2022

Ethnic Diversity of DPD Activity and the DPYD Gene: Review of the Literature.

White C et al.

Pharmacogenomics and Personalized Medicine, 2021

Improving safety of fluoropyrimidine chemotherapy by individualizing treatment based on dihydropyrimidine dehydrogenase activity - Ready for clinical practice?

Meulendijks D et al.

Cancer Treatment Reviews, 2016

Pharmacogenetic variants in the DPYD, TYMS, CDA and MTHFR genes are clinically significant predictors of fluoropyrimidine toxicity.

Loganayagam A et al.

British Journal of Cancer, 2013

Severe fluoropyrimidine-related toxicity: clinical implications of DPYD analysis and UH2/U ratio evaluation.

Giorgio E et al.

Cancer Chemotherapy and Pharmacology, 2011

Routine dihydropyrimidine dehydrogenase testing for anticipating 5-fluorouracil-related severe toxicities: hype or hope?

Ciccolini J et al.

Clinical Colorectal Cancer, 2010

[Genetic polymorphisms related to fluoropyrimidine sensitivity and toxicity].

Terashima M

Gan to Kagaku Ryoho. Cancer & Chemotherapy, 2008

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."