Associated Papers
Stabilization of Active Site Dynamics Leads to Increased Activity with 3'-Azido-3'-deoxythymidine Monophosphate for F105Y Mutant Human Thymidylate Kinase.
Fucci IJ et al.
Acs Omega, 2020
The engineered thymidylate kinase (TMPK)/AZT enzyme-prodrug axis offers efficient bystander cell killing for suicide gene therapy of cancer.
Sato T et al.
Plos One, 2013
Structures of human thymidylate kinase in complex with prodrugs: implications for the structure-based design of novel compounds.
Ostermann N et al.
Biochemistry, 2003
Potentiating AZT activation: structures of wild-type and mutant human thymidylate kinase suggest reasons for the mutants' improved kinetics with the HIV prodrug metabolite AZTMP.
Ostermann N et al.
Journal of Molecular Biology, 2000
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