Associated Papers
Dose imbalance of DYRK1A kinase causes systemic progeroid status in Down syndrome by increasing the un-repaired DNA damage and reducing LaminB1 levels.
Murray A et al.
Ebiomedicine, 2023
A novel de novo heterozygous DYRK1A mutation causes complete loss of DYRK1A function and developmental delay.
Lee KS et al.
Scientific Reports, 2020
A comprehensive proteomics-based interaction screen that links DYRK1A to RNF169 and to the DNA damage response.
Roewenstrunk J et al.
Scientific Reports, 2019
30979931 (PubMed )
Supplement: 41598_2019_42445_MOESM1_ESM.pdf
DYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies.
Ji J et al.
European Journal of Human Genetics : Ejhg, 2015
Increased dosage of the chromosome 21 ortholog Dyrk1a promotes megakaryoblastic leukemia in a murine model of Down syndrome.
Malinge S et al.
The Journal of Clinical Investigation, 2012
Transient expression of Mnb/Dyrk1a couples cell cycle exit and differentiation of neuronal precursors by inducing p27KIP1 expression and suppressing NOTCH signaling.
Hämmerle B et al.
Development (cambridge, England), 2011
DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.
Litovchick L et al.
Genes & Development, 2011
Direct association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactions.
Li D et al.
The Journal of Biological Chemistry, 2010
Regulated segregation of kinase Dyrk1A during asymmetric neural stem cell division is critical for EGFR-mediated biased signaling.
Ferron SR et al.
Cell Stem Cell, 2010
The protein kinase DYRK1A regulates caspase-9-mediated apoptosis during retina development.
Laguna A et al.
Developmental Cell, 2008
DYRK1A accumulates in splicing speckles through a novel targeting signal and induces speckle disassembly.
Alvarez M et al.
Journal of Cell Science, 2003
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