Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.R72S
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EGFR

NM_005228.5:p.R72S

Associated Papers

The - 216G/T polymorphism in the EGFR gene: A review focusing on Non-Small lung cancer.

Obradovic J et al.

Molecular Biology Reports, 2025

High Prevalence of EGFR R479K (rs2227983) Polymorphism in Indian Head and Neck Cancer Patients: Association with Unfavourable Clinical Outcome.

Ghosh A et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2025

SNP's use as a potential chemotoxicity stratification tool in breast cancer: from bench to clinic.

Moustafa HAM et al.

Functional & Integrative Genomics, 2025

Investigating the frequencies of EGFR mutations and EGFR single nucleotide polymorphisms genotypes and their predictive role in NSCLC patients in Republic of Serbia.

Obradović J et al.

Molecular Biology Reports, 2025

Single nucleotide variants in lung cancer.

Tian X et al.

Chinese Medical Journal Pulmonary and Critical Care Medicine, 2024

EPIDERMAL GROWTH FACTOR RECEPTOR (EGFR) POLYMORPHIC VARIATIONS (-216G/T & -191 C/A) POSE A HIGH RISK TO PATIENTS WITH MALIGNANT GLIOMA.

Zahoor W et al.

Experimental Oncology, 2023

A review on the genetic polymorphisms and susceptibility of cancer patients in Bangladesh.

Babu G et al.

Molecular Biology Reports, 2022

Mutational landscape of gastric adenocarcinoma in Latin America: A genetic approach for precision medicine.

Cerrato-Izaguirre D et al.

Genes & Diseases, 2022

Clinical implications of germline variations for treatment outcome and drug resistance for small molecule kinase inhibitors in patients with non-small cell lung cancer.

Heersche N et al.

Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy, 2022

Gene polymorphisms and prognosis of head and neck squamous cell carcinoma: a systematic review.

Rajabi-Moghaddam M et al.

Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology, 2022

The mineralocorticoid receptor leads to increased expression of EGFR and T-type calcium channels that support HL-1 cell hypertrophy.

Stroedecke K et al.

Scientific Reports, 2021

Polymorphisms in EGFR Gene Predict Clinical Outcome in Unresectable Non-Small Cell Lung Cancer Treated with Radiotherapy and Platinum-Based Chemoradiotherapy.

Butkiewicz D et al.

International Journal of Molecular Sciences, 2021

Pharmacogenetics for severe adverse drug reactions induced by molecular-targeted therapy.

Udagawa C et al.

Cancer Science, 2020

The Association between Epidermal Growth Factor Receptor Single Nucleotide Polymorphisms and Radiochemotherapy Response in Cervical Cancer.

Jin G et al.

Pathology Oncology Research : Por, 2020

EGFR Polymorphism and Survival of NSCLC Patients Treated with TKIs: A Systematic Review and Meta-Analysis.

Jurisic V et al.

Journal of Oncology, 2020

TP53 and DNA-repair gene polymorphisms genotyping as a low-cost lung adenocarcinoma screening tool.

Cavic M et al.

Journal of Clinical Pathology, 2019

Polymorphisms in RAS/RAF/MEK/ERK Pathway Are Associated with Gastric Cancer.

Gonzalez-Hormazabal P et al.

Genes, 2018

30597917 (PubMed )
Supplement: genes-10-00020-s001.zip › table_S1.pdf

Epidermal Growth Factor Receptor Gene in Non-Small-Cell Lung Cancer: The Importance of Promoter Polymorphism Investigation.

Jurišić V et al.

Analytical Cellular Pathology (amsterdam), 2018

Germline polymorphisms as biomarkers of tumor response in colorectal cancer patients treated with anti-EGFR monoclonal antibodies: a systematic review and meta-analysis.

Morgen EK et al.

The Pharmacogenomics Journal, 2017

Mitochondrial determinants of cancer health disparities.

Choudhury AR et al.

Seminars in Cancer Biology, 2017

Biomarker analysis of the phase 3 TORCH trial for first line erlotinib versus chemotherapy in advanced non-small cell lung cancer patients.

Kim L et al.

Oncotarget, 2017

Determinants of Gefitinib toxicity in advanced non-small cell lung cancer (NSCLC): a pharmacogenomic study of metabolic enzymes and transporters.

Ma Y et al.

The Pharmacogenomics Journal, 2017

CT characteristics in pulmonary adenocarcinoma with epidermal growth factor receptor mutation.

Zhao J et al.

Plos One, 2017

Frequencies of EGFR single nucleotide polymorphisms in non-small cell lung cancer patients and healthy individuals in the Republic of Serbia: a preliminary study.

Obradović J et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2016

Genetic Association of Curative and Adverse Reactions to Tyrosine Kinase Inhibitors in Chinese advanced Non-Small Cell Lung Cancer patients.

Ruan Y et al.

Scientific Reports, 2016

Polymorphisms in epidermal growth factor receptor (EGFR) and AKT1 as possible predictors of clinical outcome in advanced non-small-cell lung cancer patients treated with EGFR tyrosine kinase inhibitors.

Zhang X et al.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine, 2016

Correlations between EGFR gene polymorphisms and pleural metastasis of lung adenocarcinoma.

Guo H et al.

Oncotargets and Therapy, 2016

Genetic polymorphism in the epidermal growth factor receptor gene predicts outcome in advanced non-small cell lung cancer patients treated with erlotinib.

Winther-Larsen A et al.

Lung Cancer (amsterdam, Netherlands), 2015

Systematic Review of Candidate Single-nucleotide Polymorphisms as Biomarkers for Responsiveness to Neoadjuvant Chemoradiation for Rectal Cancer.

Maring ED et al.

Anticancer Research, 2015

Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach.

Karageorgos I et al.

Human Genomics, 2015

26092435 (PubMed )
Supplement: 40246_2015_34_MOESM1_ESM.xlsx › FamilyB

EGFR gene polymorphisms -216G>T and -191C>A are risk markers for gastric cancer in Mexican population.

Torres-Jasso JH et al.

Genetics and Molecular Research : Gmr, 2015

EGFR ligands and DNA repair genes: genomic predictors of complete response after capecitabine-based chemoradiotherapy in locally advanced rectal cancer.

Sebio A et al.

The Pharmacogenomics Journal, 2015

High-throughput screening identified inherited genetic variations in the EGFR pathway contributing to skin toxicity of EGFR inhibitors.

Hasheminasab SM et al.

Pharmacogenomics, 2015

Correlation between EGFR Gene Mutations and Lung Cancer: a Hospital-Based Study.

Matam K et al.

Asian Pacific Journal of Cancer Prevention : Apjcp, 2015

Sequence analysis of the Ras-MAPK pathway genes SOS1, EGFR & GRB2 in silver foxes (Vulpes vulpes): candidate genes for hereditary hyperplastic gingivitis.

Clark JA et al.

Genetica, 2014

Association of epidermal growth factor receptor (EGFR) gene polymorphism with lung cancer risk: a systematic review.

Feng X et al.

Journal of Receptor and Signal Transduction Research, 2014

Toxicity of targeted therapy: Implications for response and impact of genetic polymorphisms.

Liu S et al.

Cancer Treatment Reviews, 2014

Molecular epidemiology of lung cancer and geographic variations with special reference to EGFR mutations.

Mitsudomi T

Translational Lung Cancer Research, 2014

Intergenic polymorphisms in the amphiregulin gene region as biomarkers in metastatic colorectal cancer patients treated with anti-EGFR plus irinotecan.

Sebio A et al.

The Pharmacogenomics Journal, 2014

Molecular patterns in deficient mismatch repair colorectal tumours: results from a French prospective multicentric biological and genetic study.

Etienne-Grimaldi MC et al.

British Journal of Cancer, 2014

Epidermal growth factor receptor (EGFR) pathway genes and interstitial lung disease: an association study.

Li C et al.

Scientific Reports, 2014

Epidermal growth factor receptor gene polymorphisms are associated with prognostic features of breast cancer.

Leite MS et al.

Bmc Cancer, 2014

EGF and EGFR genetic polymorphisms predict prognosis in locally advanced pharyngolaryngeal squamous cell carcinoma patients receiving postoperative concurrent chemoradiotherapy.

Su NW et al.

Oncotargets and Therapy, 2014

Genetic variations in EGFR and ERBB4 increase susceptibility to cervical cancer.

Ma D et al.

Gynecologic Oncology, 2013

Pharmacogenetic predictors for EGFR-inhibitor-associated skin toxicity.

Parmar S et al.

The Pharmacogenomics Journal, 2013

Role of EGFR SNPs in survival of advanced lung adenocarcinoma patients treated with Gefitinib.

Zhang L et al.

Gene, 2013

Association among polymorphisms in EGFR gene exons, lifestyle and risk of gastric cancer with gender differences in Chinese Han subjects.

Zhang J et al.

Plos One, 2013

EGFR polymorphism as a predictor of clinical outcome in advanced lung cancer patients treated with EGFR-TKI.

Jung M et al.

Yonsei Medical Journal, 2012

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