Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.G465E
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EGFR

NM_005228.5:p.G465E

Associated Papers

Circulating tumor DNA profiling for non-invasive genomic analysis in Indian lung cancer patients: A real-world experience.

Jha P et al.

The Journal of Liquid Biopsy, 2025

40503459 (PubMed )
Supplement: mmc1.xlsx › Supplementary_Table_S2

Physical insights guided rational design of anti-EGFR antibody to reverse the acquired resistance.

Zhang M et al.

International Journal of Biological Macromolecules, 2025

Investigation of Exome-Wide Tumor Heterogeneity on Colorectal Tissue-Based Single Cells.

Szakállas N et al.

International Journal of Molecular Sciences, 2025

Targeted therapy guided by circulating tumor DNA analysis in advanced gastrointestinal tumors.

Nakamura Y et al.

Nature Medicine, 2025

39284955 (PubMed )
Supplement: 41591_2024_3244_MOESM2_ESM.xlsx › Suppementary_Table_1

Predictive role of [18F]FDG PET-CT radiomic parameters for KRAS/BRAF/EGFR mutations in metastatic colorectal cancer patients.

Ali MA et al.

Ejnmmi Reports, 2024

Targeting lung cancer with clinically relevant EGFR mutations using anti-EGFR RNA aptamer.

Thomas BJ et al.

Molecular Therapy. Nucleic Acids, 2023

Circulating tumor DNA landscape and prognostic impact of acquired resistance to targeted therapies in cancer patients: a national center for precision medicine (PRISM) study.

Bayle A et al.

Molecular Cancer, 2023

37924050 (PubMed )
Supplement: 12943_2023_1878_MOESM2_ESM.xlsx › Feuil1

Panitumumab Plus Trifluridine-Tipiracil as Anti-Epidermal Growth Factor Receptor Rechallenge Therapy for Refractory RAS Wild-Type Metastatic Colorectal Cancer: A Phase 2 Randomized Clinical Trial.

Napolitano S et al.

Jama Oncology, 2023

37200022 (PubMed )
Supplement: jamaoncol-e230655-s003.xlsx › eTable4

Next-Generation Sequencing on Circulating Tumor DNA in Advanced Solid Cancer: Swiss Army Knife for the Molecular Tumor Board? A Review of the Literature Focused on FDA Approved Test.

Vasseur D et al.

Cells, 2022

Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

Chevrier S et al.

International Journal of Molecular Medicine, 2022

35244186 (PubMed )
Supplement: Supplementary_Data2.xlsx › Feuil1

The Pan-Tumor Landscape of Targetable Kinase Fusions in Circulating Tumor DNA.

Lee JK et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2022

RAS and BRAF mutations in cell-free DNA are predictive for outcome of cetuximab monotherapy in patients with tissue-tested RAS wild-type advanced colorectal cancer.

van Helden EJ et al.

Molecular Oncology, 2019

31350822 (PubMed )
Supplement: MOL2-13-2361-s007.xlsx › Blad1

Patient-Derived Xenografts and Matched Cell Lines Identify Pharmacogenomic Vulnerabilities in Colorectal Cancer.

Lazzari L et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2019

Genotyping of Circulating Tumor DNA Reveals the Clinically Actionable Mutation Landscape of Advanced Colorectal Cancer.

Cao W et al.

Molecular Cancer Therapeutics, 2019

Plasma Dynamics of RAS/RAF Mutations in Patients With Metastatic Colorectal Cancer Receiving Chemotherapy and Anti-EGFR Treatment.

Thomsen CB et al.

Clinical Colorectal Cancer, 2019

A Molecularly Annotated Model of Patient-Derived Colon Cancer Stem-Like Cells to Assess Genetic and Nongenetic Mechanisms of Resistance to Anti-EGFR Therapy.

Luraghi P et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2018

28974546 (PubMed )
Supplement: 10780432ccr172151-sup-186878_2_supp_4284146_2wmpx2.xlsx › Suppl_Table-S1

Cell-Free DNA Profiling to Discover Mechanisms of Exceptional Response to Cabozantinib Plus Panitumumab in a Patient With Treatment Refractory Metastatic Colorectal Cancer.

Jia J et al.

Frontiers in Oncology, 2018

High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods.

Su D et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2017

28882180 (PubMed )
Supplement: 13046_2017_591_MOESM8_ESM.xls › Table_S8__The_golden_standard_s

Heterogeneity of Acquired Resistance to Anti-EGFR Monoclonal Antibodies in Patients with Metastatic Colorectal Cancer.

Pietrantonio F et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2017

Acquired RAS or EGFR mutations and duration of response to EGFR blockade in colorectal cancer.

Van Emburgh BO et al.

Nature Communications, 2016

27929064 (PubMed )
Supplement: ncomms13665-s1.pdf

MM-151 overcomes acquired resistance to cetuximab and panitumumab in colorectal cancers harboring EGFR extracellular domain mutations.

Arena S et al.

Science Translational Medicine, 2016

The genomic landscape of response to EGFR blockade in colorectal cancer.

Bertotti A et al.

Nature, 2015

Effectors of epidermal growth factor receptor pathway: the genetic profiling ofKRAS, BRAF, PIK3CA, NRAS mutations in colorectal cancer characteristics and personalized medicine.

Shen Y et al.

Plos One, 2013

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Regarding the variants extracted from papers and shown text snippets from research papers, the following holds: "Some rights reserved. This work permits non-commercial use, distribution and reproduction in any medium, provided the original author and source are credited."