Varaico: Literature-Extracted Genetic Variants

Gene:EGFR
Variant:p.M600K
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EGFR

NM_005228.5:p.M600K

Associated Papers

Custom multi‑tumor next‑generation sequencing panel for routine molecular diagnosis of solid tumors: Validation and results from three‑year clinical use.

Chevrier S et al.

International Journal of Molecular Medicine, 2022

35244186 (PubMed )
Supplement: Supplementary_Data2.xlsx › Feuil1

Frequency and coexistence of KRAS, NRAS, BRAF and PIK3CA mutations and occurrence of MMR deficiency in Danish colorectal cancer patients.

Poulsen TS et al.

Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, 2021

Mass Spectrometry as a Highly Sensitive Method for Specific Circulating Tumor DNA Analysis in NSCLC: A Comparison Study.

Lamy PJ et al.

Cancers, 2020

33081150 (PubMed )
Supplement: cancers-12-03002-s001.pdf

BRAF mutant colorectal cancer: ErbB2 expression levels as predictive factor for the response to combined BRAF/ErbB inhibitors.

Miele E et al.

Bmc Cancer, 2020

Precision medicine and actionable alterations in lung cancer: A single institution experience.

Mambetsariev I et al.

Plos One, 2020

32045431 (PubMed )
Supplement: pone.0228188.s005.xlsx › Sheet1

Oncogenic driver mutations in Swiss never smoker patients with lung adenocarcinoma and correlation with clinicopathologic characteristics and outcome.

Grosse C et al.

Plos One, 2019

Mutation status and prognostic values of KRAS, NRAS, BRAF and PIK3CA in 353 Chinese colorectal cancer patients.

Guo F et al.

Scientific Reports, 2018

Clinical mutational profiling of 1006 lung cancers by next generation sequencing.

Illei PB et al.

Oncotarget, 2017

29228562 (PubMed )
Supplement: oncotarget-08-96684-s001.pdf

Mutational profiling of acral melanomas in Korean populations.

Shim JH et al.

Experimental Dermatology, 2017

High performance of targeted next generation sequencing on variance detection in clinical tumor specimens in comparison with current conventional methods.

Su D et al.

Journal of Experimental & Clinical Cancer Research : Cr, 2017

28882180 (PubMed )
Supplement: 13046_2017_591_MOESM8_ESM.xls › Table_S8__The_golden_standard_s

"Squirrel" Primer-Based PCR Assay for Direct and Targeted Sanger Sequencing of Short Genomic Segments.

Ebili HO et al.

Journal of Biomolecular Techniques : Jbt, 2017

Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma.

Franczak C et al.

Molecular Diagnosis & Therapy, 2017

Hot spot mutations in Finnish non-small cell lung cancers.

Mäki-Nevala S et al.

Lung Cancer (amsterdam, Netherlands), 2016

Genetic and epigenetic aberrations occurring in colorectal tumors associated with serrated pathway.

Sakai E et al.

International Journal of Cancer, 2016

26510091 (PubMed )
Supplement: IJC-138-1634-s001.pdf

Oncolytic reovirus in combination with chemotherapy in metastatic or recurrent non-small cell lung cancer patients with KRAS-activated tumors.

Villalona-Calero MA et al.

Cancer, 2016

Quantitative Detection and Resolution of BRAF V600 Status in Colorectal Cancer Using Droplet Digital PCR and a Novel Wild-Type Negative Assay.

Bidshahri R et al.

The Journal of Molecular Diagnostics : Jmd, 2016

Building a Robust Tumor Profiling Program: Synergy between Next-Generation Sequencing and Targeted Single-Gene Testing.

Hiemenz MC et al.

Plos One, 2016

27043212 (PubMed )
Supplement: pone.0152851.s001.xlsx › BRAF

Rapid targeted somatic mutation analysis of solid tumors in routine clinical diagnostics.

Magliacane G et al.

Oncotarget, 2015

A retrospective observational study of clinicopathological features of KRAS, NRAS, BRAF and PIK3CA mutations in Japanese patients with metastatic colorectal cancer.

Kawazoe A et al.

Bmc Cancer, 2015

25886136 (PubMed )
Supplement: 12885_2015_1276_MOESM1_ESM.xlsx › Addtional_file_1

BRAF V600E mutation and KRAS codon 13 mutations predict poor survival in Chinese colorectal cancer patients.

Chen J et al.

Bmc Cancer, 2014

Performance of amplicon-based next generation DNA sequencing for diagnostic gene mutation profiling in oncopathology.

Sie D et al.

Cellular Oncology (dordrecht, Netherlands), 2014

A very low incidence of BRAF mutations in Middle Eastern colorectal carcinoma.

Siraj AK et al.

Molecular Cancer, 2014

BRAF pyrosequencing analysis aided by a lookup table.

Olson MT et al.

American Journal of Clinical Pathology, 2014

Conjunctival melanomas harbor BRAF and NRAS mutations and copy number changes similar to cutaneous and mucosal melanomas.

Griewank KG et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2013

[The detection of activating somatic mutations in gene KRAS using pyrosequencing technique].

Dribnokhodova OP et al.

Klinicheskaia Laboratornaia Diagnostika, 2013

Allele-specific, non-extendable primer blocker PCR (AS-NEPB-PCR) for DNA mutation detection in cancer.

Wang H et al.

The Journal of Molecular Diagnostics : Jmd, 2013

Pattern of clinically relevant mutations in consecutive series of Russian colorectal cancer patients.

Yanus GA et al.

Medical Oncology (northwood, London, England), 2013

Survey of KRAS, BRAF and PIK3CA mutational status in 209 consecutive Italian colorectal cancer patients.

Bozzao C et al.

The International Journal of Biological Markers, 2012

Characteristics and prevalence of KRAS, BRAF, and PIK3CA mutations in colorectal cancer by high-resolution melting analysis in Taiwanese population.

Hsieh LL et al.

Clinica Chimica Acta; International Journal of Clinical Chemistry, 2012

[Polymorphism of ABCB1 and ABCG2 genes encoding drug transporters and their investigation by pyrosequencing].

Dribnokhodova OP et al.

Eksperimental'naia I Klinicheskaia Farmakologiia, 2012

Mechanism of EGER-related cancer drug resistance.

Wei X

Anti-cancer Drugs, 2011

KRAS mutation is associated with lung metastasis in patients with curatively resected colorectal cancer.

Tie J et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2011

21239505 (PubMed )
Supplement: 10780432ccr101720-sup-supplementary_tables_s1-s4.pdf

KRas and BRaf mutational status analysis from formalin-fixed, paraffin-embedded tissues using multiplex polymerase chain reaction-based assay.

Jakubauskas A et al.

Archives of Pathology & Laboratory Medicine, 2010

RAF expression in human astrocytic tumors.

Hagemann C et al.

International Journal of Molecular Medicine, 2009

Mutation analysis of the EGFR-NRAS-BRAF pathway in melanomas from black Africans and other subgroups of cutaneous melanoma.

Akslen LA et al.

Melanoma Research, 2008

Mutational analysis of EGFR and related signaling pathway genes in lung adenocarcinomas identifies a novel somatic kinase domain mutation in FGFR4.

Marks JL et al.

Plos One, 2007

17487277 (PubMed )
Supplement: pone.0000426.s004.doc

Mutation analysis of 24 known cancer genes in the NCI-60 cell line set.

Ikediobi ON et al.

Molecular Cancer Therapeutics, 2006

Molecular alterations in tumors and response to combination chemotherapy with gefitinib for advanced colorectal cancer.

Ogino S et al.

Clinical Cancer Research : an Official Journal of the American Association for Cancer Research, 2005

BRAF--a new player in hematological neoplasms.

Machnicki MM et al.

Blood Cells, Molecules & Diseases, 0

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